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Full-Text Articles in Genetics and Genomics
Localization And Expression Of The Aer Receptor In Escherichia Coli, Daniel Salcedo
Localization And Expression Of The Aer Receptor In Escherichia Coli, Daniel Salcedo
Loma Linda University Electronic Theses, Dissertations & Projects
In Escherichia coli, chemotactic movement towards an energetically-favorable environment is mediated by five transmembrane chemoreceptors. These sensory proteins respond to numerous environmental signals, including amino acids, sugars, and pH. The aerotaxis receptor, Aer, is an intracellular sensor that responds to oxygen concentration and other parameters affecting cellular energy levels. Bacterial chemotaxis receptors form dimeric signaling units that organize into tetramers and hexamers and form large clusters at the cell poles. A cluster arrangement could increase receptor sensitivity by lateral communication between dimers, thus amplifying the signal from one dimer. We have shown that Aer forms dimers, trimer of dimers, …
Contribution Of Ledgf/P75 To Prostate Cancer Chemoresistance, Melanie Mediavilla-Varela
Contribution Of Ledgf/P75 To Prostate Cancer Chemoresistance, Melanie Mediavilla-Varela
Loma Linda University Electronic Theses, Dissertations & Projects
Prostate cancer (PCa) is the second leading cause of male cancer death in the United States, and is considered a health disparity because of its disproportionate incidence and mortality in African American (AA) males. A major challenge in PCa treatment is its recurrence into hormone refractory prostate cancer (HRPC). Docetaxel is the standard of care for first line chemotherapy to HRPC. Unfortunately, most patients ultimately manifest resistance to DTX and succumb to the disease. Circumventing DTX resistance in HRPC will require better understanding of the mechanisms by which this drug kills prostate tumor cells, and the genes that promote this …