Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Bioinformatics (2)
- Cell and Developmental Biology (2)
- Molecular Genetics (2)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
-
- Cancer Biology (1)
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
- Developmental Biology (1)
- Diseases (1)
- Environmental Health (1)
- Genomics (1)
- Immunology and Infectious Disease (1)
- Immunology of Infectious Disease (1)
- Medicine and Health Sciences (1)
- Microbiology (1)
- Molecular Biology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Toxicology (1)
- Institution
Articles 1 - 3 of 3
Full-Text Articles in Genetics and Genomics
Expression Profiling Of Non-Coding Rna By Environmental Interactions In Innate Immunity, Jacob R. Longfellow
Expression Profiling Of Non-Coding Rna By Environmental Interactions In Innate Immunity, Jacob R. Longfellow
Electronic Theses and Dissertations
Cystic fibrosis (CF) is a genetic disorder that affects 30,000 people in the United States and currently has no cure. Although CF affects all of the body’s systems, it is largely characterized as a lung disease. CF is caused by a mutation in both copies of the gene for cystic fibrosis transmembrane conductance regulator (CFTR). A mutation in the CFTR gene leads to improper movement of chloride ions and water into the airways, which dysregulates the airway surface liquid volume and composition. Individuals with CF are prone to lung infections due to inefficient bacterial clearance and by the age of …
Non-Coding Rnas Identify The Intrinsic Molecular Subtypes Of Muscle-Invasive Bladder Cancer, Andrea E. Ochoa
Non-Coding Rnas Identify The Intrinsic Molecular Subtypes Of Muscle-Invasive Bladder Cancer, Andrea E. Ochoa
Dissertations & Theses (Open Access)
NON-CODING RNAS IDENTIFY THE INTRINSIC MOLECULAR SUBTYPES OF MUSCLE-INVASIVE BLADDER CANCER
Andrea Elizabeth Ochoa, B.S.
Advisory Professors: David J. McConkey, Ph.D. and Joya Chandra, Ph.D.
There has been a recent explosion of genomics data in muscle-invasive bladder cancer (MIBC) to better understand the underlying biology of the disease that leads to the high amount of heterogeneity that is seen clinically. These studies have identified relatively stable intrinsic molecular subtypes of MIBC that show similarities to the basal and luminal subtypes of breast cancer. However, previous studies have primarily focused on protein-coding genes or DNA mutations/alterations.
There is emerging evidence implicating …
Investigating Mirna Functions In Arabidopsis By Short Tandem Target Mimic (Sttm), Yiyou Gu
Investigating Mirna Functions In Arabidopsis By Short Tandem Target Mimic (Sttm), Yiyou Gu
Dissertations, Master's Theses and Master's Reports
MicroRNA (miRNAs) and other endogenous small RNAs play important role in regulating gene expression in eukaryotes. Till now, several techniques have been developed for miRNA function analysis. Because of the characteristic of miRNAs, the most applicable method for miRNA function research is blocking the whole miRNA family specifically. Here, we report an artificial non-coding transcript termed Short Tandem Target Mimic (STTM) for blocking miRNA activity in Arabidopsis thaliana. The STTM composed of two miRNA target sites with three nucleotides bulge in the miRNA cleavage site, the two-miRNA targets separated by spacer linker. We used this technique blocking several important endogenous …