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Articles 1 - 7 of 7
Full-Text Articles in Genetics and Genomics
Npgreat: Hybrid Assembly Of Human Subtelomeres With The Use Of Nanopore And Linked-Read Datasets, Eleni Adam, Desh Ranjan, Harold Riethman
Npgreat: Hybrid Assembly Of Human Subtelomeres With The Use Of Nanopore And Linked-Read Datasets, Eleni Adam, Desh Ranjan, Harold Riethman
College of Sciences Posters
The telomeres are vitally important regions that are located at the tips of the chromosomes. Their dysfunction, caused by length shortening can lead to senescent cells, which in turn cause age-related diseases, including cancer. The subtelomeres, located next to the telomeres, possess the critical role of regulating the adjacent telomere lengths. Even after many years of research, human subtelomeres have proven to be very hard to assemble due to their morphology. In order to overcome these problems, the hybrid assembly method we develop utilizes two of the latest available types of data, which complement each other: Linked-Reads and ultralong Nanopore …
Tip60 Regulation Of Δnp63Α Is Associated With Cisplatin Resistance, Akshay Hira, Andrew Stacy, Jin Zhang, Michael P. Craig, Madhavi Kadakia
Tip60 Regulation Of Δnp63Α Is Associated With Cisplatin Resistance, Akshay Hira, Andrew Stacy, Jin Zhang, Michael P. Craig, Madhavi Kadakia
Symposium of Student Research, Scholarship, and Creative Activities Materials
About 5.4 million basal and squamous cell skin cancers are diagnosed every year in the US. ΔNp63a, a member of the p53 transcription factor family, is overexpressed in non-melanoma skin cancer and regulates cell survival, migration and invasion. TIP60 is histone acetyltransferase (HAT) which mediates cellular processes such as transcription and the DNA damage response (DDR). Previous studies in our lab have shown that overexpression of TIP60 induces ΔNp63a protein stabilization in a catalytic-dependent manner. Since ΔNp63a is known to transcriptionally regulate several DDR genes and promote cisplatin resistance, its stabilization by TIP60 may contribute to the failure of platinum-based …
Liver Ubd Is Upregulated In The Lew.1wr1 Rat, Helen Gibson, Amelia Clopp, Genoah Collins
Liver Ubd Is Upregulated In The Lew.1wr1 Rat, Helen Gibson, Amelia Clopp, Genoah Collins
Research Horizons Day Posters
No abstract provided.
Sandy Winters: Creation And Destruction, Shannon Egan
Sandy Winters: Creation And Destruction, Shannon Egan
Schmucker Art Catalogs
The title of Sandy Winters’s exhibition is a bit of a misnomer, as the process that perhaps best describes the artist’s practice is creation and re-creation. The evolution of her long and active career reveals a sensitive awareness of connectivity and progeny. In other words, she allows for her paintings, prints, drawings, and sculpture to give birth in a way to subsequent works. She continually recognizes the pregnant possibilities in a singular form and the opportunities for each to exist in new, unique environments. Aspects of Winters’s oeuvre seem to have a generative function, and these repetitive motifs exist as …
My Genetic Code And What It Says About Me, Josiah Lane
My Genetic Code And What It Says About Me, Josiah Lane
Summer Community of Scholars Posters (RCEU and HCR Combined Programs)
No abstract provided.
The Regulatory Role Of Tnac In The Universal Expression Regulation Of Rf-2 Dependent Regulons, Chi Pham
The Regulatory Role Of Tnac In The Universal Expression Regulation Of Rf-2 Dependent Regulons, Chi Pham
Summer Community of Scholars Posters (RCEU and HCR Combined Programs)
No abstract provided.
Belief In Genetic Determinism Within Academic Levels, Miranda Massmann, Katie Humrick, Linda Fuselier
Belief In Genetic Determinism Within Academic Levels, Miranda Massmann, Katie Humrick, Linda Fuselier
Undergraduate Arts and Research Showcase
Belief in genetic determinism (BGD) is the belief that genes attribute more influence on the expression of traits than scientific research supports. The environment and other factors, such as epigenetics, factor heavily into the expression of traits and it is important that students from all backgrounds understand this since BGD has been associated with societal instances of racism and sexism. We analyzed essay responses that undergraduate students wrote in response to a socioscientific issue (SSI) about the use of CRISPR/Cas9 technology for non-medical enhancement in humans to examine the presence of BGD. Our sample was composed of non-biology majors, lower …