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Hypoglycemia In Mitochondrial Disorders, Allison Moats
Hypoglycemia In Mitochondrial Disorders, Allison Moats
Dissertations & Theses (Open Access)
INTRODUCTION: The electron transport chain (ETC) in mitochondria functions to produce energy in the form of adenosine triphosphate (ATP). Defects in the mitochondrial or nuclear DNA that codes for components of the ETC lead to mitochondrial disorders (MTDs). MTDs are multi-system conditions affecting the heart, muscles, and especially brain. The endocrine system is commonly affected in MTDs, and diabetes and hyperglycemia are established secondary diagnoses. Rates of non-iatrogenic hypoglycemia have not been studied in individuals with MTDs. This study aims to investigate the frequency of hypoglycemia in patients with MTDs.
METHODS: Individuals diagnosed with a ‘definite’ or ‘probable’ …