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Full-Text Articles in Genetics and Genomics
Transcriptome Profiling Of Saccharomyces Cerevisiae Mutants Lacking C2h2 Zinc Finger Proteins, Jinghe Mao, Tanwir Habib, Ming Shenwu, Baobin Kang, Wilbur Allen, Lashonda Robertson, Jack Y. Yang, Youping Deng
Transcriptome Profiling Of Saccharomyces Cerevisiae Mutants Lacking C2h2 Zinc Finger Proteins, Jinghe Mao, Tanwir Habib, Ming Shenwu, Baobin Kang, Wilbur Allen, Lashonda Robertson, Jack Y. Yang, Youping Deng
Faculty Publications
Background
The budding yeast Saccharomyces cerevisiae is a eukaryotic organism with extensive genetic redundancy. Large-scale gene deletion analysis has shown that over 80% of the ~6200 predicted genes are nonessential and that the functions of 30% of all ORFs remain unclassified, implying that yeast cells can tolerate deletion of a substantial number of individual genes. For example, a class of zinc finger proteins containing C2H2 zinc fingers in tandem arrays of two or three is predicted to be transcription factors; however, seven of the thirty-one predicted genes of this class are nonessential, and their functions are poorly understood. In this …