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Cocaine dependence attentional bias serotonin polymorphisms impulsivity
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Full-Text Articles in Genetics and Genomics
Cocaine Dependence: The Role Of Serotonin Genes In, Lorena Maili
Cocaine Dependence: The Role Of Serotonin Genes In, Lorena Maili
Dissertations & Theses (Open Access)
Animal studies have shown that behavioral responses to cocaine-related cues are altered by serotonergic medications. The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the disruption of cocaine-associated memories. One measure of cocaine related cues in humans is attentional bias, in which cocaine dependent individuals show greater response latency for cocaine related words than neutral words. Data from our laboratory shows that cocaine dependent subjects have altered attentional bias compared to controls. The purpose of this thesis was to investigate the role of the …