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Full-Text Articles in Genetics and Genomics
Plasma Activated Air Mediates Gene Transfer, Chelsea M. Edelblute
Plasma Activated Air Mediates Gene Transfer, Chelsea M. Edelblute
Biological Sciences Theses & Dissertations
Cold plasma is produced when strong applied electric fields accelerate free electrons, which dissociate, excite, or ionize gaseous molecules [1]. The deposition of ions from the plasma source is dependent on power generation, input gas composition, and gas flow rate. In the presence of reactive species, the membrane of eukaryotic cells is compromised allowing for otherwise impermeant molecules, such as DNA, to enter the inner-cell milieu [2].
The efficacy of a novel cold plasma reactor based on shielded sliding discharge for the delivery of plasmid DNA was assessed. The device is entirely non-contact, wherein the plasma never directly touches the …
De Novo Protein Structure Modeling And Energy Function Design, Lin Chen
De Novo Protein Structure Modeling And Energy Function Design, Lin Chen
Computer Science Theses & Dissertations
The two major challenges in protein structure prediction problems are (1) the lack of an accurate energy function and (2) the lack of an efficient search algorithm. A protein energy function accurately describing the interaction between residues is able to supervise the optimization of a protein conformation, as well as select native or native-like structures from numerous possible conformations. An efficient search algorithm must be able to reduce a conformational space to a reasonable size without missing the native conformation. My PhD research studies focused on these two directions.
A protein energy function—the distance and orientation dependent energy function of …