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Full-Text Articles in Genetics and Genomics
Ptsd, Alcohol Dependence, And Conduct Problems: Distinct Pathways Via Lability And Disinhibition, Jeffrey S. Simons, Raluca M. Simons, Carol O'Brien, Scott F. Stoltenberg, Jessica A. Keith, Jaime A. Hudson
Ptsd, Alcohol Dependence, And Conduct Problems: Distinct Pathways Via Lability And Disinhibition, Jeffrey S. Simons, Raluca M. Simons, Carol O'Brien, Scott F. Stoltenberg, Jessica A. Keith, Jaime A. Hudson
Department of Psychology: Faculty Publications
This study tested the role of affect lability and disinhibition in mediating associations between PTSD symptoms and two forms of alcohol-related problems, dependence syndrome symptoms (e.g., impaired control over consumption) and conduct problems (e.g., assault, risk behaviors). Genotype at the serotonin transporter linked polymorphic region (5-HTTLPR) was hypothesized to moderate associations between traumatic stress and PTSD symptoms. In addition, the study tested whether childhood traumatic stress moderated associations between combat trauma and PTSD symptoms. Participants were 270 OIF/OEF/OND veterans. The hypothesized model was largely supported. Participants with the low expression alleles of 5-HTTLPR (S or LG) exhibited stronger …
A Concept Analysis Of Resilience Integrating Genetics, Kosuke Niitsu, Julia F. Houfek, Cecilia R. Barron, Scott F. Stoltenberg, Kevin A. Kupzyk, Michael J. Rice
A Concept Analysis Of Resilience Integrating Genetics, Kosuke Niitsu, Julia F. Houfek, Cecilia R. Barron, Scott F. Stoltenberg, Kevin A. Kupzyk, Michael J. Rice
Department of Psychology: Faculty Publications
Although clinicians and researchers are interested in the phenomenon of resilience, there is no agreed-upon definition of resilience. Scientific evidence suggests that resilience is influenced by intrapersonal (e.g., personality traits) and environmental (e.g., social support) variables. A concept analysis was conducted to better understand the meaning of resilience. In this analysis, the antecedent of resilience was a potentially traumatic event; the defining attributes were ego-resiliency, emotion regulation, social support, and heredity; and the consequences were none to mild psychopathological symptoms and positive adaptation. This analysis can help nurses better understand resilience and its relationships …
A Systematic Review And Secondary Data Analysis Of The Interactions Between The Serotonin Transporter 5-Httlpr Polymorphism And Environmental And Psychological Factors In Eating Disorders, Vanja Rozenblat, Deborah Ong, Matthew Fuller-Tyszkiewicz, Kirsti Akkermann, David Collier, Rutger C. M. E. Engels, Fernando Fernandez-Aranda, Jaanus Harro, Judith R. Homberg, Andreas Karwautz, Evelyn Kiive, Kelly K. Klump, Sarah E. Racine, Jodie Richardson, Howard Steiger, Scott F. Stoltenberg, Tatjana Van Strien, Gudrun Wagner, Janet Treasure, Isabel Krug
A Systematic Review And Secondary Data Analysis Of The Interactions Between The Serotonin Transporter 5-Httlpr Polymorphism And Environmental And Psychological Factors In Eating Disorders, Vanja Rozenblat, Deborah Ong, Matthew Fuller-Tyszkiewicz, Kirsti Akkermann, David Collier, Rutger C. M. E. Engels, Fernando Fernandez-Aranda, Jaanus Harro, Judith R. Homberg, Andreas Karwautz, Evelyn Kiive, Kelly K. Klump, Sarah E. Racine, Jodie Richardson, Howard Steiger, Scott F. Stoltenberg, Tatjana Van Strien, Gudrun Wagner, Janet Treasure, Isabel Krug
Department of Psychology: Faculty Publications
Objectives: To summarize and synthesize the growing gene × environment (G × E) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. Method: A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets …