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Full-Text Articles in Genetics and Genomics
Epigenetic Activation Of The Mouse T Cell Receptor Beta Recombination Center, Jiangyang Zhao
Epigenetic Activation Of The Mouse T Cell Receptor Beta Recombination Center, Jiangyang Zhao
Arts & Sciences Electronic Theses and Dissertations
Lymphocytes are the work horses of adaptive immunity. Compared to the B lymphocyte lineage, early stage progenitors of T lymphocytes maintain considerable potential for differentiation into other hematopoietic lineages. T lineage commitment requires the continuous coordination of transcription factors (TFs) by Notch1 signaling after multi-potent progenitors (MPPs) migrate to thymus. One of the first hall marks of T lineage commitment is expression of the T cell receptor β (TCRβ), which is encoded by the Tcrb locus following its assembly by V(D)J recombination, a somatic shuffling of the genome that joins one V, one D, and one J gene segment. Tcrb …
The Effects Of The Gut Microbiota On The Host Chromatin Landscape, Nicholas Semenkovich
The Effects Of The Gut Microbiota On The Host Chromatin Landscape, Nicholas Semenkovich
Arts & Sciences Electronic Theses and Dissertations
The human gut microbiota is home to tens of trillions of microbes belonging to all three domains of life. The structure and expressed functions of this community have myriad effects on host physiology, metabolism, and immune function. My studies focused on a facet of host-microbial interactions and mutualism that has not been explored to a significant degree in part because of the absence of suitable tools: namely, if, when, and how the gut microbiota produces durable effects on host biology through its impact on the epigenome. To address this area, I turned to gnotobiotic mice and developed a variety of …