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Full-Text Articles in Genetics and Genomics
Mutations In Ikaros Lead To An Altered Epigenetic And Chromatin Landscape Contributing To The Manifestation Of B-Cell Related Disorders, Princess Rodriguez
Mutations In Ikaros Lead To An Altered Epigenetic And Chromatin Landscape Contributing To The Manifestation Of B-Cell Related Disorders, Princess Rodriguez
Graduate College Dissertations and Theses
IKAROS is expressed throughout the entire hematopoietic system and is required for lymphoid commitment and subsequent differentiation towards the B-lymphoid fate. If absent, progenitor and mature B-cell subsets are not expressed. IKAROS (encoded by IKZF1) is a zinc-finger transcription factor shown to regulate gene expression either directly or through the recruitment of chromatin remodeling complexes. The epigenetic gene regulatory mechanisms, including the posttranslational modification to histone proteins, as well as the expression of noncoding RNAs (ncRNAs) are important to control as perturbations in these processes contribute to the manifestation of human diseases. If left unregulated, uncontrolled growth, aberrant cell activation, …