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Full-Text Articles in Genetics and Genomics
The Role Of The Bps Immunity Repressor In The Regulation Of Pathogenic Mycobacterium Chelonae Gene Expression, Emma Freeman
The Role Of The Bps Immunity Repressor In The Regulation Of Pathogenic Mycobacterium Chelonae Gene Expression, Emma Freeman
Honors College
Mycobacterium tuberculosis is the leading cause of death by an infectious disease (MacNeil, 2019). In 2018, 10 million people developed tuberculosis and half a million infections were resistant to antibiotics (WHO, 2019). Nearly all members of the M. tuberculosis complex are lysogens, meaning they carry prophage, or integrated viral genomes within the host genome (Fan et al., 2016). The non-pathogenic vaccine strain (M. bovis Bacillus Calmette–Guérin (BCG)) is the exception, which suggests prophage play a role in virulence (Fan et al., 2016). Because not all prophage encode obvious virulence genes, we hypothesize that prophage impact bacterial virulence by altering bacterial …
Pathogen-Mediated Evolution Of Immunogenetic Variation In Plains Zebra (Equus Quagga) Of Southern Africa, Pauline L. Kamath
Pathogen-Mediated Evolution Of Immunogenetic Variation In Plains Zebra (Equus Quagga) Of Southern Africa, Pauline L. Kamath
Animal and Veterinary Sciences Faculty Scholarship
Investigating patterns of variability in functional protein-coding genes is fundamental to identifying the basis for population and species adaptation and ultimately, for predicting evolutionary potential in the face of environmental change. The Major Histocompatibility Complex (MHC), a family of immune genes, has been one of the most emphasized gene systems for studying selection and adaptation in vertebrates due to its significance in pathogen recognition and consequently, in eliciting host immune response. Pathogen evasion of host resistance is thought to be the primary mechanism preserving extreme levels of MHC polymorphism and shaping immunogenetic patterns across host populations and species. In this …