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Articles 1 - 6 of 6
Full-Text Articles in Genetics and Genomics
Dynamics Of Hybrid Zones At A Continental Scale, Bradley T. Martin
Dynamics Of Hybrid Zones At A Continental Scale, Bradley T. Martin
Graduate Theses and Dissertations
Hybridization has traditionally been viewed as a happenstance that negatively impacts populations, but is now recognized as an important evolutionary mechanism that can substantially impact the evolutionary trajectories of gene pools, influence adaptive capacity, and contravene or reinforce divergence. Physiographic processes are important drivers of dispersal, alternately funneling populations into isolation, promoting divergence, or facilitating secondary contact of diverged populations, increasing the potential for hybridization. In North America, glacial-interglacial cycles and geomorphological changes have provided a dynamic backdrop over the last two million years that promoted such oscillations of population contraction and expansion. These biogeographic processes have resulted in regional …
Chasing The Genetics Of Ascites In Broilers Using Whole Genome Resequencing, Alia Parveen
Chasing The Genetics Of Ascites In Broilers Using Whole Genome Resequencing, Alia Parveen
Graduate Theses and Dissertations
We are using whole genome resequencing to identify chromosomal regions associated with resistance or susceptibility to ascites, a form of pulmonary hypertension syndrome, meat-type chickens. Previous Genome Wide Association Studies (GWAS) based on Single Nucleotide Polymorphisms (SNPs) have identified regions on chromosomes 2, 9 and Z. Despite several GWAS and further genotyping, there are no reliable or potential markers for ascites phenotype. We have completed screening of Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms in ascites resistant and susceptible birds from the relaxed, REL, line derived from a commercial elite broiler line. DNA samples from resistant and susceptible birds …
Involvement Of The Ino80 Complex In Chromosome Segregation, Jesus Moreno
Involvement Of The Ino80 Complex In Chromosome Segregation, Jesus Moreno
Graduate Theses and Dissertations
Chromatin remodeling complexes are multi-protein complexes that regulate the dynamics of the nucleosomes in the genome. The INO80 chromatin remodeling complex participates in varied biological processes such as: transcription, DNA repair, DNA replication and chromosome integrity. It catalyzes the eviction of the H2A.Z variant histone as well as whole nucleosome eviction. This complex is comprised of 15 subunits and the contribution of each to chromosome segregations remains unknown. To evaluate the contribution of each subunit to chromosome segregation, we tested deletion mutants of the non-essential subunits for DNA content and benomyl sensitivity. Also, we assessed members of the SWR1 and …
Phylogeny And Evolutionary Genomics Of Non-Photosynthetic Diatoms, Anastasiia Onyshchenko
Phylogeny And Evolutionary Genomics Of Non-Photosynthetic Diatoms, Anastasiia Onyshchenko
Graduate Theses and Dissertations
Diatoms are prolific photosynthesizers responsible for some 20% of global primary production. In real terms, the oxygen in one of every five breaths traces back to photosynthesis by marine diatoms. Among the tens of thousands of diatom species, a small handful of colorless diatom species in the genus Nitzschia have lost photosynthesis altogether and rely exclusively on extracellular organic carbon for growth. I used DNA sequence data to reconstruct the phylogeny of this group, and found that nonphotosynthetic diatoms are monophyletic, indicating that photosynthesis was lost just one time over the course of some 200 million years of diatom evolution. …
Bayesian Network Modeling And Inference Of Gwas Catalog, Qiuping Pan
Bayesian Network Modeling And Inference Of Gwas Catalog, Qiuping Pan
Graduate Theses and Dissertations
Genome-wide association studies (GWASs) have received an increasing attention to understand genotype-phenotype relationships. The Bayesian network has been proposed as a powerful tool for modeling single-nucleotide polymorphism (SNP)-trait associations due to its advantage in addressing the high computational complex and high dimensional problems. Most current works learn the interactions among genotypes and phenotypes from the raw genotype data. However, due to the privacy issue, genotype information is sensitive and should be handled by complying with specific restrictions. In this work, we aim to build Bayesian networks from publicly released GWAS statistics to explicitly reveal the conditional dependency between SNPs and …
Transcriptome-Based Gene Networks For Systems-Level Analysis Of Plant Gene Functions, Chirag Gupta
Transcriptome-Based Gene Networks For Systems-Level Analysis Of Plant Gene Functions, Chirag Gupta
Graduate Theses and Dissertations
Present day genomic technologies are evolving at an unprecedented rate, allowing interrogation of
cellular activities with increasing breadth and depth. However, we know very little about how the
genome functions and what the identified genes do. The lack of functional annotations of genes
greatly limits the post-analytical interpretation of new high throughput genomic datasets. For plant
biologists, the problem is much severe. Less than 50% of all the identified genes in the model plant
Arabidopsis thaliana, and only about 20% of all genes in the crop model Oryza sativa have some
aspects of their functions assigned. Therefore, there is an …