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2020

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Full-Text Articles in Food Science

Reducing Calories Of Margarins, Khodjaev Sarvar, Abdurakhimov Saidakbar, Akramova Rano Dec 2020

Reducing Calories Of Margarins, Khodjaev Sarvar, Abdurakhimov Saidakbar, Akramova Rano

CHEMISTRY AND CHEMICAL ENGINEERING

The goal is to reduce the calorie content of margarines by changing the composition and fat base. In this regard, we studied the change in caloric content and the content of trans-acids in margarines with a change in their fat content. To reduce calorie content, the fat base of margarine was also reduced to 60%, and to increase the biological value of the product, it was enriched with highly unsaturated fatty acids. It was determined that with an increase in the number of unsaturated fatty acids and a decrease in the margarine fat content, the stability of the emulsion deteriorates. …

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Chromatographic Analysis Of The Effect Of Catalyst Quantities On The Hydrogenization Process, Rakhimov Dilshod, Ruzibayev Akbarali, Eyupov Edem, Dadamukhamedov Khojiakbar Dec 2020

Chromatographic Analysis Of The Effect Of Catalyst Quantities On The Hydrogenization Process, Rakhimov Dilshod, Ruzibayev Akbarali, Eyupov Edem, Dadamukhamedov Khojiakbar

CHEMISTRY AND CHEMICAL ENGINEERING

Oil and fat industry is one of the important sectors of the food industry. Salomas (Hydrogenated oil) for food and technical purposes are the main components of margarine products, toilet, household soaps, various technological lubricants, cosmetic creams and can be used as valuable chemical raw materials. Objective: ox work is to study the effect of the amount of catalyst on the hydrogenation of cottonseed oil by chromatographic analysis of the resulting salomas. It is confirmed that an increase in the amount of the catalyst from 0.05 to 0.4% increases the melting point of salomas and reduces the iodine number, which …

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Extraction Of Unsaturated Fatty Acids From Vegetable Oils, Pecherskaya Mariya, Mamatkulov Shavkat, Ruzimuradov Olim, Butanov Khakimjan Dec 2020

Extraction Of Unsaturated Fatty Acids From Vegetable Oils, Pecherskaya Mariya, Mamatkulov Shavkat, Ruzimuradov Olim, Butanov Khakimjan

CHEMISTRY AND CHEMICAL ENGINEERING

The article studies the possibility of extraction of monounsaturated oleic acid from highly stable vegetable oils produced at industrial scale. To solve the set tasks, have been selected samples of vegetable oils, present in the domestic market with a high content of unsaturated fatty acids: cottonseed and sunflower, imported rapeseed and olive oils. These oil samples were degraded by hydrolysis, recovered by acid treatment, and purified by repeated recrystallization in ethanol. The composition of saturated and unsaturated fatty acids included in triglycerides of vegetable oils was investigated using gas chromatography-mass spectrometry (GC-MS). In the obtained samples, the fatty acid composition …

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Water-Soluble Jerusalem Artichoke Extracts As Fat Replacer In Dietary Margarine Recipe, Salijanova Shahnozaxon, Ruzibayev Akbarali, Rakhimov Dilshod, Xusanov Zafar Dec 2020

Water-Soluble Jerusalem Artichoke Extracts As Fat Replacer In Dietary Margarine Recipe, Salijanova Shahnozaxon, Ruzibayev Akbarali, Rakhimov Dilshod, Xusanov Zafar

CHEMISTRY AND CHEMICAL ENGINEERING

Creating dietary margarines using biologically valuable substances is the purpose of the work. According to the results of the experiments, it was found that the use of soybean oil, edible vegetable phospholipids and a Jerusalem artichoke extract in the margarine, allowed reducing the amount of fat and enriching the margarine with omega-3 and omega-6 fatty acids, dietary fibre, inulin and other water-soluble substances. Based on these studies prepared margarine enriched inulin and essential fatty acids, which provide not only a preventive property of the finished product, but also high flavor indicators, as well as, original and attractive appearance.

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Lemongrass (Cymbopogon Citratus) Ethanolic Extract Exhibited Activities That Inhibit -Glucosidase Enzymes And Postprandial Blood Glucose Elevation, Maria Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Felicia Melissa Tjiptadi, Phebe Hendra, Filiana Santoso, Zalinar Udin, Nina Artanti, Florence Ignatia Florence Ignatia Dec 2020

Lemongrass (Cymbopogon Citratus) Ethanolic Extract Exhibited Activities That Inhibit -Glucosidase Enzymes And Postprandial Blood Glucose Elevation, Maria Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Felicia Melissa Tjiptadi, Phebe Hendra, Filiana Santoso, Zalinar Udin, Nina Artanti, Florence Ignatia Florence Ignatia

Makara Journal of Science

Lemongrass is a common ingredient in Indonesian traditional herbal medicine that potently inhibits carbohydrate hydrolysis. In this study, the in vitro α-glucosidase inhibitory (AGI) activity of lemongrass was compared with its in vivo activity to retard postprandial blood glucose elevation, and the bioactive compounds responsible for these activities were observed. Both water and ethanolic extracts of lemongrass (WLG and ELG, respectively) were tested in vitro for its inhibition of the sucrose and maltose hydrolyzing activities of rat intestinal glucosidase. ELG was observed to exert higher inhibitory activities (Sucrase IC50 = 8.74 mg/mL; Maltase IC50 = 18.93 mg/mL) than …

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Acknowledgment Of Reviewers, Lily Chiu Dec 2020

Acknowledgment Of Reviewers, Lily Chiu

Journal of Food and Drug Analysis

No abstract provided.

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The Analytical And Biomedical Applications Of Carbon Dots And Their Future Theranostic Potential: A Review, Sukunya Ross, Ren-Siang Wu, Shih-Chun Wei, Gareth M. Ross, Huan-Tsung Chang Dec 2020

The Analytical And Biomedical Applications Of Carbon Dots And Their Future Theranostic Potential: A Review, Sukunya Ross, Ren-Siang Wu, Shih-Chun Wei, Gareth M. Ross, Huan-Tsung Chang

Journal of Food and Drug Analysis

In recent years, carbon dots (C-dots) have gained appreciable interest owing to their unique optical properties, including tunable fluorescence, stability against photobleaching and photoblinking, and strong fluorescence. Simple and low-cost hydrothermal and electrochemical approaches have been widely used in the preparation of biocompatible and high-quality C-dots. Various C-dots have been used for the quantitation of small analytes, mostly based on analyte induced fluorescence quenching. Depending on the nature of precursors, synthetic conditions (such as reaction temperature and time), and surface conjugation, multi-function C-dots can be prepared and used in diagnostics and therapeutics. Their strong fluorescence and photostability, enables use in …

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Nanomaterial-Based Adsorbents And Optical Sensors For Illicit Drug Analysis, Chun-Hsien Chen, Chun-Chi Wang, Po-Yun Ko, Yen-Ling Chen Dec 2020

Nanomaterial-Based Adsorbents And Optical Sensors For Illicit Drug Analysis, Chun-Hsien Chen, Chun-Chi Wang, Po-Yun Ko, Yen-Ling Chen

Journal of Food and Drug Analysis

The abuse of illicit drugs has been prevalent in recent years and is associated with crime and public health issues. To strengthen public security and fortify public health services with respect to the increasing severity of drug abuse, academic and government institutes have been devoted to constructing relative analytical methods for illicit drugs. To date, the development of sensors has been greatly emphasized due to their features of high sensitivity, prompt detection and flexible manipulation; thus, sensors can serve as alternatives to conventional sophisticated instruments. Recently, the use of nanomaterials has inspired the development of a series of innovative sample …

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Gold Nanoparticle-Based Colorimetric And Electrochemical Sensors For The Detection Of Illegal Food Additives, Li Li, Ming Zhang, Wei Chen Dec 2020

Gold Nanoparticle-Based Colorimetric And Electrochemical Sensors For The Detection Of Illegal Food Additives, Li Li, Ming Zhang, Wei Chen

Journal of Food and Drug Analysis

Lately, scandals associated with the illegal addition of poisonous chemicals to food for commercial interests have been gradually disclosed to the public. Problems related to food safety do not only harm public health but also affect the stability of economic and social development. Food safety has become a common issue in society, and strengthening the related regulations have become increasingly important. Although conventional techniques are accurate and sensitive in the detection of the vast majority of illegal food additives, they rely on time-consuming, labor-intensive procedures that depend on expensive instruments. Thus, efficient and rapid identification of poisonous, illegal additives in …

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Improved Food Additive Analysis By Ever-Increasing Nanotechnology, Jing Zhang, Shui Hu, Yi Du, Ding Cao, Guirong Wang, Zhiqin Yuan Dec 2020

Improved Food Additive Analysis By Ever-Increasing Nanotechnology, Jing Zhang, Shui Hu, Yi Du, Ding Cao, Guirong Wang, Zhiqin Yuan

Journal of Food and Drug Analysis

Improper use of food additives may lead to potential threat to human health, making it important to develop sensitive and selective method for the detection of them. Nanomaterials with unique chemical and electrochemical properties show extensive applications in the design of food additive sensing systems. In this review, we summarize the recently adopted electrochemical and optical analysis of food additives based on nanomaterials. Detection of typical food additives (colorants and preservatives) by using different sensing mechanisms and strategies are provided. In addition, determination of illegal food additives is also briefly introduced. Finally, this review highlights the challenges and future trend …

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Electrowetting-On-Dielectric (Ewod): Current Perspectives And Applications In Ensuring Food Safety, Snigdha Roy Barman, Imran Khan, Subhodeep Chatterjee, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin Dec 2020

Electrowetting-On-Dielectric (Ewod): Current Perspectives And Applications In Ensuring Food Safety, Snigdha Roy Barman, Imran Khan, Subhodeep Chatterjee, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin

Journal of Food and Drug Analysis

Digital microfluidic (DMF) platforms have contributed immensely to the development of multifunctional lab-on-chip systems for performing complete sets of biological and analytical assays. Electrowetting-on-dielectric (EWOD) technology, due to its outstanding flexibility and integrability, has emerged as a promising candidate for such lab-on-chip applications. Triggered by an electrical stimulus, EWOD devices allow precise manipulation of single droplets along the designed electrode arrays without employing external pumps and valves, thereby enhancing the miniaturization and portability of the system towards transcending important laboratory assays in resource-limited settings. In recent years, the simple fabrication process and reprogrammable architecture of EWOD chips have led to …

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Nanomaterial-Based Fluorescent Biosensor For Veterinary Drug Detection In Foods, Xiaoqi Tao, Yuanyuan Peng, Juewen Liu Dec 2020

Nanomaterial-Based Fluorescent Biosensor For Veterinary Drug Detection In Foods, Xiaoqi Tao, Yuanyuan Peng, Juewen Liu

Journal of Food and Drug Analysis

Veterinary drugs have been widely used in the food industry. Their residues in food products need to be tightly regulated to ensure food safety. In particular, some veterinary drugs are still used illegally, although they have already been banned. Nanomaterials are playing an increasingly important role in analytical chemistry due to their unique properties. Compared to traditional organic dyes and colloidal gold nanoparticle labels, fluorescent nanomaterials appear particularly attractive for the detection of veterinary drug residues. This review summarizes recent advancements of fluorescent biosensors using nanomaterials for the detection of veterinary drug residues in foods. The useful properties of each …

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Carbon Quantum Dots For The Detection Of Antibiotics And Pesticides, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Yang-Wei Lin, Chih-Ching Huang Dec 2020

Carbon Quantum Dots For The Detection Of Antibiotics And Pesticides, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Yang-Wei Lin, Chih-Ching Huang

Journal of Food and Drug Analysis

Carbon quantum dots (CQDs) are novel nanomaterials with interesting physical and chemical properties, which are intensely studied only in the last decade. Unique properties, such as its inherent fluorescent property, high resistance to photobleaching, high surface area, ease of synthesis, flexible choice of precursor, and surface tunability enable CQDs for promising application in biosensing. Therefore, it is highly useful in clinical, forensic, medical, food and drug analyses, disease diagnosis, and various other fields of biosensing. In addition, their fluorescence properties are tunable by the interaction with certain molecules via different mechanisms, which enables their application for sensing of those molecules, …

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Noble Metal Nanomaterial-Based Aptasensors For Microbial Toxin Detection, Yue He, Cong-Ying Wen, Zhi-Jun Guo, Yu-Fen Huang Dec 2020

Noble Metal Nanomaterial-Based Aptasensors For Microbial Toxin Detection, Yue He, Cong-Ying Wen, Zhi-Jun Guo, Yu-Fen Huang

Journal of Food and Drug Analysis

Microbial toxins generated by bacteria, fungi and algae cause serious food-safety problems due to the frequent contamination of foodstuffs and their poisonous nature. Becoming acquainted with the contamination condition of foodstuffs is highly dependent on developing sensitive, specific, and accurate methods for targeting microbial toxins. Aptamers, obtained from systematic evolution of ligands by exponential enrichment (SELEX), have significant advantages for microbial toxin analysis, such as small size, reproducible chemical synthesis, and modification, as well as high binding affinity, specificity, and stability. Besides, aptamers have a predictable structure and can be tailored using biomolecular tools (e.g., ligase, endonuclease, exonuclease, …

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Perspective On Recent Developments Of Nanomaterial Based Fluorescent Sensors: Applications In Safety And Quality Control Of Food And Beverages, Ailing Han, Sijia Hao, Yayu Yang, Xia Li, Xiaoyu Luo, Guozhen Fang, Jifeng Liu, Shuo Wang Dec 2020

Perspective On Recent Developments Of Nanomaterial Based Fluorescent Sensors: Applications In Safety And Quality Control Of Food And Beverages, Ailing Han, Sijia Hao, Yayu Yang, Xia Li, Xiaoyu Luo, Guozhen Fang, Jifeng Liu, Shuo Wang

Journal of Food and Drug Analysis

As the highly toxic pollutants will seriously harm human health, it is particularly important to establish the analysis and detection technology of food pollutants. Compared with the traditional detection methods, fluorescent detection technique based on nanomaterials trigger wide interesting because of reduced detection time, simple operation, high sensitivity and selectivity and economic. In this review, the application of fluorescent sensors in food pollutants detection is presented. Firstly, conventional fluorescent nanomaterials including metal-based quantum dots, carbon-based quantum dots and metal nanoclusters were summarized, with emphasis on the photoluminescence mechanism. Then, the fluorescence sensors based on these nanomaterials for food pollutants detection …

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Preface, Huan-Tsung Chang, Yu-Fen Huang Dec 2020

Preface, Huan-Tsung Chang, Yu-Fen Huang

Journal of Food and Drug Analysis

No abstract provided.

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Let's Stop Worrying And Learn To Love Transparency: Food And Technology In The Information Age, Scarlettah Schaefer Nov 2020

Let's Stop Worrying And Learn To Love Transparency: Food And Technology In The Information Age, Scarlettah Schaefer

Journal of Food Law & Policy

Food and technology have had a long and tempestuous relationship. Current methods of food production and processing in the industrialized world depend heavily on technological developments. However, all technologies are not created equal. Some can produce food that is safer, more sustainable, more nutritious, or longer lasting. Some can have the opposite effect: increasing opportunities for adulteration, increasing the difficulty in detecting food fraud, and contributing to both foreseeable and unforeseeable health or ecological costs. Increasingly sophisticated technologies often become less apparent to the average consumer. For example, consider irradiated meat or genetically modified foods as opposed to freezer storage …

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Method For Using Soya Grain Juice In Production Of Pasta Products, Sanaev Ermat, Tursunkhodjaev Po'lat, Ayhodjaeva Nodira, Umarov Orif Oct 2020

Method For Using Soya Grain Juice In Production Of Pasta Products, Sanaev Ermat, Tursunkhodjaev Po'lat, Ayhodjaeva Nodira, Umarov Orif

CHEMISTRY AND CHEMICAL ENGINEERING

Considering the protein need for human nutrition, the use of protein-rich grains plays an important role in the production of pasta. The study used soy protein as one of the protein sources, which serves as an effective source of energy in the physical and mental activities of humans. In the form of nutritious juice from soybeans, a protein concentration of 4.67% was obtained, and the resulting soy juice, rich in proteins, was used as an unconventional raw material for the production of pasta. Concentrations and methods were identified that made it possible to achieve technological and economic efficiency.

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The Effect Of Hydrothermal Treatment In Increasing The Strength Of The Shell Of Wheat Grain In Preparation For Varietal Grinding, Ravshanov Suvankul, Mirzayev Jamol, Musaev Khasanjon Oct 2020

The Effect Of Hydrothermal Treatment In Increasing The Strength Of The Shell Of Wheat Grain In Preparation For Varietal Grinding, Ravshanov Suvankul, Mirzayev Jamol, Musaev Khasanjon

CHEMISTRY AND CHEMICAL ENGINEERING

The effect of hydrothermal treatment on the strength of the wheat grain shell before the first torn process is investigated. It was found that the anatomical parts of wheat grains grown in arid climatic conditions are firmly interconnected, which, in turn, affects the yield and quality of varietal flour. The aim of the study is to weaken strong native connections and improve the yield and quality of flour. The effect of NaHCO3, H3PO4, CH3COOH, HCl additives to water on the yield and quality of flour was studied. Accordingly, in solutions of 0.1-0.2% hydrochloric acid and 0.3-0.8% phosphoric acid, an increase …

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Innovative Cotton Oil Refining Technology, Majidova Nargiza, Sattarov Karim, Majidov Kaxramon, Ismatov Sunatillo Oct 2020

Innovative Cotton Oil Refining Technology, Majidova Nargiza, Sattarov Karim, Majidov Kaxramon, Ismatov Sunatillo

CHEMISTRY AND CHEMICAL ENGINEERING

The results of partial and final refining of raw cottonseed oil by solution of aluminates and and sodium hydroxide are given. The intensification of the technological process is carried out by the treatment of alkaline solutions by exposure to electromagnetic field intensity. Increase in yield and quality improvement of refined oil is achieved.

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New Composition And Method For Producing Pasta, Sanaev Ermat, Tursunkhodjaev Pulat, Ayhodjaeva Nodira, Normatov Anvar Oct 2020

New Composition And Method For Producing Pasta, Sanaev Ermat, Tursunkhodjaev Pulat, Ayhodjaeva Nodira, Normatov Anvar

CHEMISTRY AND CHEMICAL ENGINEERING

The main objective of this study is to develop a composition of pasta containing a mixture of ginger, lemon and mint powder, as well as a combination of legumes and cereals with high nutritional value. This will expand the range of pasta. The problem of achieving high quality and economic efficiency is solved by improving several technological processes and using innovative methods. The effectiveness of using innovative methods of sublimation and microwave drying is shown in comparison with the drying process of instant pasta by frying it in vegetable oil.

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Research Of The Process Of Obtaining Interesterified Fat For Margarine Production On The Basis Of Sunflower Oil And Palm Stearin, Rahimov Dilshod, Ruziboyev Akbarali, Tashmuratov Asatullo, Salijanova Shaxnoza Oct 2020

Research Of The Process Of Obtaining Interesterified Fat For Margarine Production On The Basis Of Sunflower Oil And Palm Stearin, Rahimov Dilshod, Ruziboyev Akbarali, Tashmuratov Asatullo, Salijanova Shaxnoza

CHEMISTRY AND CHEMICAL ENGINEERING

The study presents the results of transesterification of a mixture of sunflower oil and palm stearin in various proportions and dilatometric analysis of the obtained transesterifications was carried out. For example, the ratios in the mixture of sunflower oil and palm stearin 15/85, 25/75, 30/70, 50/50 were subjected to transesterification in the laboratory, and the transesterifications used for the spread and margarine were obtained, and the optimal mixture ratios were determined. By dilatometric analysis, it was found that it is possible to obtain interesterificates in the ratio of a mixture of sunflower oil and palm stearin at 50/50 for a …

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A Mechanistic Study On The Non-Genotoxic Carcinogenicity Of The Food Contaminant Semicarbazide, Daniel P. Fitzpatrick Oct 2020

A Mechanistic Study On The Non-Genotoxic Carcinogenicity Of The Food Contaminant Semicarbazide, Daniel P. Fitzpatrick

SURE Journal: Science Undergraduate Research Experience Journal

Semicarbazide was brought to the forefront of scientific discussions by the scientific community in the early 2000’s as the substance was discovered in several food products from both synthetic and natural sources. Although semicarbazide was processed through several toxicological assays and classified as a non-genotoxic carcinogen, underwhelming amounts of toxicological data exists for the compound. The present study is one of the first in-vitro studies to examine the relationship between sub-pathophysiological concentrations of reactive oxygen species and the anomalous non-genotoxic carcinogenicity induced by semicarbazide through the upregulation of intracellular signalling pathways. A novel finding of the present study was where …

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Production Of Laban Immo Powder: Process Andcharacteristics Of The Obtained Product, Hoda Saadeddine Saad Elmasri Lebanese International University, Lebanon, Ossama Dimassi Lebanese International University, Lebanon Sep 2020

Production Of Laban Immo Powder: Process Andcharacteristics Of The Obtained Product, Hoda Saadeddine Saad Elmasri Lebanese International University, Lebanon, Ossama Dimassi Lebanese International University, Lebanon

BAU Journal - Health and Wellbeing

Busy life styles and unconventional working hours made the task of getting a meal on the table really challenging thus leading to the trend of consuming easy-to-prepare meals. Lebanon is still behind in having ready to prepare traditional meals available in the market. Laban immo is a traditional Lebanese dish which contains essential nutrients that allows it to be labeled as nutritionally balanced. The primary objective of this study is to produce laban immo in a powdered form that is shelf stable, convenient, easy to prepare and portable. Previous research conducted in this area was able to successfully produce yogurt …

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Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh Aug 2020

Corrigendum To “Physicochemical Analysis And Nonisothermal Kinetic Study Of Sertralineelactose Binary Mixtures”, Farnaz Monajjemzadeh

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng Aug 2020

Corrigendum To “Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng Aug 2020

Corrigendum To “The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng Aug 2020

Corrigendum To “Effects Of Aqueous Extract Of Ruta Graveolens And Its Ingredients On Cytochrome P450, Uridine Diphosphate (Udp)-Glucuronosyltransferase, And Reduced Nicotinamide Adenine Dinucleotide (Phosphate) (Nad(P)H)-Quinone Oxidoreductase In Mice”, Yune- Fang Ueng

Journal of Food and Drug Analysis

No abstract provided.

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Detection Of Melamine Based On The Suppressed Anodic Response Of Uric Acid By A Au-Ag Nanoparticles Modified Glassy Carbon Electrode, Yu-Hui Peng, Tsunghsueh Wu, Yang-Wei Lin Aug 2020

Detection Of Melamine Based On The Suppressed Anodic Response Of Uric Acid By A Au-Ag Nanoparticles Modified Glassy Carbon Electrode, Yu-Hui Peng, Tsunghsueh Wu, Yang-Wei Lin

Journal of Food and Drug Analysis

We demonstrated a sensitive electrochemical method for the determination of non-electroactive melamine (Mel) using a modified glassy carbon electrode (GCE), with uric acid (UA) as the signal reporter. To increase the anodic response of UA, GCE was coated with Au–Ag nanoparticles and a Nafion thin film (Au–Ag/Nafion/GCE). The sensing mechanism was based on the competitive adsorption behavior of Mel on the Au–Ag/Nafion/GCE, which reduces the electroactive surface area of nanoparticles and thus hinders anodic response of UA. Under optimal conditions and the use of an analytical method of differential pulse voltammetry, this modified electrode detected Mel concentrations ranging from 2.5 …

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Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang Aug 2020

Acarbose Attenuates Migration/Proliferation Via Targeting Microrna-143 In Vascular Smooth Muscle Cells Under Diabetic Conditions, Wei-Yuan Chuang, Meng-Hsun Yu, Tsung-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang

Journal of Food and Drug Analysis

Acarbose (an a-glucosidase inhibitor) has been demonstrated to reduce the progression of atherosclerosis without affecting serum levels of glucose in rabbits fed a high cholesterol diet. The main focus of recent atherosclerosis studies has been microRNA targets. However, the mechanism by which acarbose targets miRNA-mediated atherosclerosis remains unclear. This study aimed to evaluate the effect of acarbose on microRNA-related regulation of rat aortic vascular smooth cell line (A7r5 cell) migration and proliferation induced by diabetic conditions. We reported that acabose exhibit significantly inhibits proliferative and cell migration abilities in A7r5 cells. The expression of protein and levels of mRNA were …

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