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Study Of In Vitro Bioaccessibility And In Vivo Bioavailability Of Khalas Variety Date Seed Polyphenols For Functional Application In The Human Diet, Serene Hilary

Food Science Dissertations

Date seeds are an ideal source of polyphenols for the food industry. This doctoral work investigated Khalas variety date seeds in three forms, as powder (DSP), ethanolic extract (DSE) and functional food developed with the seeds; pita bread (DSB). The study characterised the polyphenol profile by mass spectrometry and investigated the bioaccessibility using simulated in vitro digestion coupled with Caco- 2 model for absorption and transport. It further explored the bioavailability of date seed polyphenols in vivo in humans by conducting a cross-over study in 16 healthy volunteers. The crossover study explored the urinary excretion of polyphenol metabolites, and the …