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Single-Dose Oral Challenges To Validate Eliciting Doses In Children With Cow’S Milk Allergy, Paul J. Turner, Yvonne M. D'Art, Bettina Duca, Sophia A. Chastell, Guadalupe Marco-Martin, Rosialzira N. Vera-Berrios, Olaya Alvarez, Raphaëlle Bazire, Pablo Rodríguez Del Río, Marta Vazquez-Ortiz, Joseph L. Baumert, Ronald Van Ree, Clare E.N. Mills, Montserrat Fernandez-Rivas, Jonathan O.B. Hourihane

Department of Food Science and Technology: Faculty Publications

Background: There is increasing interest in the use of eliciting doses (EDs) to inform allergen risk management. The ED can be estimated from the distribution of threshold doses for allergic subjects undergoing food challenges within a specified population. Estimated ED₀₅ values for cow's milk (the dose expected to cause objective allergic symptoms in 5% of the milk-allergic population) range from 0.5 mg to 13.9 mg cow's milk protein. We undertook a single-dose challenge study to validate a predicted ED₀₅ for cow's milk of 0.5 mg protein.

Methods: Participants were recruited from 4 clinical centres. Predetermined criteria were used …