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Articles 1 - 4 of 4
Full-Text Articles in Ecology and Evolutionary Biology
Molecular Mechanisms Shaping Host Range Of A Vector-Borne Pathogen, Thomas Macgregor Hart
Molecular Mechanisms Shaping Host Range Of A Vector-Borne Pathogen, Thomas Macgregor Hart
Legacy Theses & Dissertations (2009 - 2024)
Vector-borne diseases, such as Lyme disease caused by Borrelia burgdorferi sensu lato (Bbsl), have narrow host ranges and are apt models to study host-microparasite coevolution. Some species and strains of Lyme borreliae (LB) are specialists, infecting only mammalian or only avian hosts (ex. Borrelia afzelii and B. garinii, respectively), while others are generalists and infect both hosts (ex. B. burgdorferi). Such host tropisms are hypothesized to be partially shaped by the ability of these pathogens evade host immune defenses, such as complement. Complement is a first line host defense against invading pathogens that kills LB in vitro and inhibits spirochete …
Intra And Interhost Dynamics Shaping Arbovirus Adaptation And Evolution, Alexander T. Ciota
Intra And Interhost Dynamics Shaping Arbovirus Adaptation And Evolution, Alexander T. Ciota
Legacy Theses & Dissertations (2009 - 2024)
Arthropod-borne viruses (arboviruses), which are predominately mosquito-borne and almost exclusively RNA viruses, are maintained in nature in complex transmission cycles involving blood sucking invertebrates and vertebrate hosts. Although over 120 arboviruses are human pathogens responsible for causing a significant and expanding global health burden, a detailed understanding of the complex interactions between these pathogens and their hosts, particularly invertebrate hosts, is lacking. Defining these interactions is necessary if we are to understand the selective pressures and, therefore, evolutionary, adaptive, and epidemiological potential of arboviruses. This requires experimental infection and evolution studies, particularly in vivo, with natural hosts. The results presented …
Evaluation Of A Biopesticide Against Invasive Species For Native Species Restoration, Denise Ann Mayer
Evaluation Of A Biopesticide Against Invasive Species For Native Species Restoration, Denise Ann Mayer
Legacy Theses & Dissertations (2009 - 2024)
Since their introduction in the 1980s, dreissenid mussels (Dreissena polymorpha and D. rostriformis bugensis) rapidly spread throughout North America and have had severe impacts on the ecology of freshwater ecosystems. A project was initiated in the early 1990s at the New York State Museum's Field Research Laboratory to discover and develop natural products to control industrial biofouling by dreissenid mussels. A strain of Pseudomonas fluorescens (Pf-CL145A), isolated from the sediment of a North American river, was found to be effective at killing dreissenids. The strain was patented for this use.
The Impact Of Environment On Virulence Of The Pathogenic Yeast Cryptococcus Gattii, Deborah Jean Springer
The Impact Of Environment On Virulence Of The Pathogenic Yeast Cryptococcus Gattii, Deborah Jean Springer
Legacy Theses & Dissertations (2009 - 2024)
Four serotypes of Cryptococcus are responsible for most human and animal infections. C. gattii , serotype B and C, are the primary the causative agent of cryptococcosis in immune competent individuals whilst, C. neoformans var. neoformans serotype D, and C. neoformans var. grubii serotype A are most prevalent in immunocompromised hosts world-wide. C. gattii is recognized as a species distinct from C. neoformans based on differences in clinical manifestations, morphology, biological characteristics, and environmental niche. We used the plant model Arabidopsis thaliana plants and plant derived substrates as a model to explore C. gattii interactions in its ecological niche. C. …