Cell and Developmental Biology Commons^™

The Developmental Implications Of The Regulatory Relationship Between Cjun And Oct4 In Murine Embryonic Stem Cells, Rachel E. Brewer

Cal Poly Humboldt theses and projects

As cells transition from the point of fertilization through the process of embryonic development, many molecular changes occur that affect cell fate. At the blastocyst stage, the earliest distinction, two separate cell populations arise. The trophectoderm cells will generate all of the extraembryonic tissues while the inner cell mass will yield all of the embryonic tissues. These cells, which generate the organism, are termed pluripotent at this stage and found within the inner cell mass (ICM). A variety of genetic mechanisms that regulate this event have been characterized. Here, we examined the effect of cJun expression in regulating Oct4, a …