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Full-Text Articles in Cell and Developmental Biology
Biological Signatures Of Vaccine Responses, Lorena Nunez
Biological Signatures Of Vaccine Responses, Lorena Nunez
Honors Scholar Theses
The set of host- and pathogen-specific molecular features of a disease comprise its “signature”. We hypothesize that biological signatures enables distinctions between vaccinated vs. infected individuals. In our research, using porcine samples, protocols were developed that could also be used to identify biological signatures of human disease. Different classes of molecular features will be tested during this project, including indicators of basic immune capacity, which are being studied at this instance.
These indicators of basic immune response such as porcine cytokines and antibodies were validated using Enzyme-linked immunosorbent assay (ELISA). This is an established method that detects antigens by their …
Investigating The Affects Of Cucurbitacin-I On Cellular Motility, Rebecca Lafleur
Investigating The Affects Of Cucurbitacin-I On Cellular Motility, Rebecca Lafleur
Honors Scholar Theses
Cellular migration is an integral component of many biological processes including immune function, wound healing and cancer cell metastasis. A complete model illustrating the mechanism by which cells accomplish movement is still lacking. Exploring the affects of various drugs on cell motility may be instrumental in discovering new proteins which mediate cell movement. This project aims ultimately to characterize the molecular target of the drug Cucurbitacin-I, a natural plant product. This drug has been shown to inhibit migration of epithelial sheets and may have anti-tumor activity.
In this paper, we show that Cucurbitacin-I inhibits the migration of MDCK and B16F1 …