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Cell and Developmental Biology Commons™
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- Atoh1 (2)
- Cerebellum (2)
- Development (2)
- Glutamatergic neurons (2)
- Granule cells (2)
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- MAPK signaling (2)
- Medulloblastoma (2)
- Neurons (2)
- Purkinje cells (2)
- Shh (2)
- Biological signatures (1)
- Cdc73 (1)
- Chaperone proteins (1)
- Embyronic stem cells (1)
- Endogenous (1)
- FMD (1)
- Functional (1)
- GCSPRI (1)
- HPT-JT (1)
- Hyperparathyroidism-jaw tumor syndrome (1)
- IPS cells (1)
- Ischemia (1)
- Microbiome (1)
- Ossifying jaw fibromas (1)
- Parafibromin (1)
- Recovery (1)
- Stroke (1)
- Transcription factors (1)
Articles 1 - 6 of 6
Full-Text Articles in Cell and Developmental Biology
The Effects Of Mapk Signaling On The Development Of Cerebellar Granule Cells, Kerry Morgan
The Effects Of Mapk Signaling On The Development Of Cerebellar Granule Cells, Kerry Morgan
University Scholar Projects
The granule cells are the most abundant neuronal type in the human brain. Rapid proliferation of granule cell progenitors results in dramatic expansion and folding of the cerebellar cortex during postnatal development. Mis-regulation of this proliferation process causes medulloblastoma, the most prevalent childhood brain tumor. In the developing cerebellum, granule cells are derived from Atoh1-expressing cells, which arise from the upper rhombic lip (the interface between the roof plate and neuroepithelium). In addition to granule cells, the Atoh1 lineage also gives rise to different types of neurons including cerebellar nuclei neurons. In the current study, I have investigated the …
The Effects Of Mapk Signaling On The Development Of Cerebellar Granule Cells, Kerry Morgan
The Effects Of Mapk Signaling On The Development Of Cerebellar Granule Cells, Kerry Morgan
Honors Scholar Theses
The granule cells are the most abundant neuronal type in the human brain. Rapid proliferation of granule cell progenitors results in dramatic expansion and folding of the cerebellar cortex during postnatal development. Mis-regulation of this proliferation process causes medulloblastoma, the most prevalent childhood brain tumor. In the developing cerebellum, granule cells are derived from Atoh1-expressing cells, which arise from the upper rhombic lip (the interface between the roof plate and neuroepithelium). In addition to granule cells, the Atoh1 lineage also gives rise to different types of neurons including cerebellar nuclei neurons. In the current study, I have investigated the …
Embryonic Lethality Of Cranial Neural Crest Deletion Of Cdc73, Lilia Shen
Embryonic Lethality Of Cranial Neural Crest Deletion Of Cdc73, Lilia Shen
Honors Scholar Theses
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a disease characterized by parathyroid tumors, renal cysts or tumors, uterine tumors, and ossifying jaw fibromas. The cause of this syndrome is linked to a tumor suppressor gene called Cdc73, which encodes the protein product parafibromin. The loss of proper expression of Cdc73/parafibromin is implicated in the development of the tumors typical of HPT-JT, although the exact mechanisms of tumorigenesis are unclear. In particular, not much is understood about the development of ossifying fibromas (OF) of the jaw in this syndrome. OF is a benign bone neoplasm that can affect the mandible and …
Manipulation Of The Microbiome And Its Impact On Functional Recovery Following Ischemic Stroke, Michal Jandzinski
Manipulation Of The Microbiome And Its Impact On Functional Recovery Following Ischemic Stroke, Michal Jandzinski
Honors Scholar Theses
Each year, nearly 800,000 individuals residing in the United States will have a stroke. Of these, about 130,000 cases will prove fatal while many of the survivors will be forced to live with disability for the remainder of their lives. Out of all strokes over 87% are ischemic strokes. The widespread incidence of this debilitating condition costs the United States an estimated $36.5 billion dollars every single year. Despite this, clinicians are armed with very little to combat the disease. Recent research developments have brought about the rise in awareness about the importance of the microbiome, the various gut flora …
Optimization Of Protein Expression Of Four Transcription Factors Using Chaperone Proteins, Kaitlin Wilson
Optimization Of Protein Expression Of Four Transcription Factors Using Chaperone Proteins, Kaitlin Wilson
Honors Scholar Theses
Embryonic stem cells are unique in their ability to grow indefinitely while maintaining both pluripotency and self-renewal capabilities. These stem cells could be the answer to solving many of the debilitating and devastating diseases suffered by humans. Recently, the use of human derived embryonic stem cells has been effective in animal models in the treatment of spinal cord injuries (Kierstead et al., 2005).
Although the study of embryonic stem cells has become increasingly popular in the last decade, there is still much research to be done to increase the expression of valuable embryonic proteins which will induce pluripotency in the …
Biological Signatures Of Vaccine Responses, Lorena Nunez
Biological Signatures Of Vaccine Responses, Lorena Nunez
Honors Scholar Theses
The set of host- and pathogen-specific molecular features of a disease comprise its “signature”. We hypothesize that biological signatures enables distinctions between vaccinated vs. infected individuals. In our research, using porcine samples, protocols were developed that could also be used to identify biological signatures of human disease. Different classes of molecular features will be tested during this project, including indicators of basic immune capacity, which are being studied at this instance.
These indicators of basic immune response such as porcine cytokines and antibodies were validated using Enzyme-linked immunosorbent assay (ELISA). This is an established method that detects antigens by their …