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7 Alpha-Hydroxy-Beta-Sitosterol From Chisocheton Tomentosus Induces Apoptosis Via Dysregulation Of Cellular Bax/Bcl-2 Ratio And Cell Cycle Arrest By Downregulating Erk1/2 Activation, Noor Hasima Nagoor
Noor Hasima Nagoor
In continuation of our interest towards the elucidation of apoptotic pathways of cytotoxic phytocompounds, we have embarked upon a study on the anticancer effects of 7 alpha-hydroxy-beta-sitosterol (CT1), a rare natural phytosterol oxide isolated from Chisocheton tomentosus. CT1 was found to be cytotoxic on three different human tumor cell lines with minimal effects on normal cell controls, where cell viability levels were maintained >= 80% upon treatment. Our results showed that cell death in MCF-7 breast tumor cells was achieved through the induction of apoptosis via downregulation of the ERK1/2 signaling pathway. CT1 was also found to increase proapoptotic Bax …