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Full-Text Articles in Cell and Developmental Biology
Transcriptional And Epigenetic Regulation Of Cerebellar Development And Function, Naveen C. Reddy
Transcriptional And Epigenetic Regulation Of Cerebellar Development And Function, Naveen C. Reddy
Arts & Sciences Electronic Theses and Dissertations
Precise control of gene expression is essential for neural development and function. This control is regulated by the interplay of chromatin remodelers and transcription factors (TFs). To better understand these mechanisms involved in gene regulation, we pursue two questions: 1) what are the roles of the chromatin remodeler CHD7 in cerebellar development and 2) what are the roles of the MEF2 TF family in cerebellar function. CHD7 mutations are causative for CHARGE syndrome, a heterogeneous disorder affecting many organ systems, occurring in 1:10,000 newborns. Recent MRI studies have identified cerebellar hypoplasia and foliation defects in a large portion of CHARGE …
Fgf20 In Olfactory System And Cochlea Development, Lu Morgan Yang
Fgf20 In Olfactory System And Cochlea Development, Lu Morgan Yang
Arts & Sciences Electronic Theses and Dissertations
The olfactory epithelium (OE) is a neurosensory organ required for the sense of smell. Turbinates, bony projections from the nasal cavity wall, increase the surface area within the nasal cavity lined by the OE. We identified a population of OE progenitor cells that expand horizontally during development to populate all lineages of the mature OE and increase OE surface area. We show that these Fgf20-positive, epithelium-spanning progenitor (FEP) cells are responsive to Wnt/β-Catenin signaling. Wnt signaling suppresses FEP cell differentiation into OE basal progenitors and their progeny, and positively regulates Fgf20 expression. We further show that FGF20 signals to the …