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Full-Text Articles in Cell and Developmental Biology
Functional Importance Of Lipin Phosphorylation, Stephanie Elizabeth Hood
Functional Importance Of Lipin Phosphorylation, Stephanie Elizabeth Hood
Graduate Theses and Dissertations
Highly conserved throughout evolution, lipins are dual functioning proteins found from yeast to humans. Functioning in the cytoplasm as phosphatidate phosphatase enzymes (PAP), lipins produce diacylglycerol that serves as a precursor for neutral fats and membrane phospholipids. Alternatively, nuclear lipins are responsible for the regulation of metabolic genes. Interestingly, both the mammalian lipin 1 paralog and the single Drosophila Lipin ortholog are highly phosphorylated proteins. Target of rapamycin (TOR) has previously been identified as one of the kinases that controls the subcellular localization of both lipin 1 and Drosophila Lipin. However, other serine and threonine kinases are predicted to be …
The Functional And Structural Analysis Of Drosophila Robo2 In Axon Guidance, Lafreda Janae Howard
The Functional And Structural Analysis Of Drosophila Robo2 In Axon Guidance, Lafreda Janae Howard
Graduate Theses and Dissertations
In animals with complex nervous systems such as mammals and insects, signaling pathways are responsible for guiding axons to their appropriate synaptic targets. Importantly, when this process is not successful during the development of an organism, outcomes include catastrophes such as human neurological diseases and disorders. It is vital to determine the underlying causes of such diseases by understanding the development of the nervous system. There are many pathways that have been identified to play a role in this, however, we lack an understanding of how these pathways can promote such diverse outcomes in different populations of neurons. These pathways …