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Full-Text Articles in Cell and Developmental Biology
The Role Of Calcium In Regulation Of Glial Cell Line Derived Neurotrophic Factor By Skeletal Muscle Cells, Alicia M. Boynton
The Role Of Calcium In Regulation Of Glial Cell Line Derived Neurotrophic Factor By Skeletal Muscle Cells, Alicia M. Boynton
Masters Theses
Glial cell line-derived neurotrophic factor (GDNF) is an important signaling molecule for the somatic motor nervous system. GDNF protein is produced and secreted by skeletal muscle cells and helps maintain motor neuron innervation at the neuromuscular junction. Treatment with exogenous GDNF prevents denervation which is characteristic of aging and neurodegenerative disease. The therapeutic potential of GDNF cannot be fully explored without understanding the mechanisms by which GDNF protein production is regulated. The primary objective of this study was to determine the role of calcium in regulating GDNF protein expression by skeletal muscle cells. Skeletal muscle cells (C2C12) were grown in …