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Articles 1 - 3 of 3
Full-Text Articles in Biotechnology
The Role Of Foxd1 In Clear Cell Renal Cell Carcinoma, Kyle H. Bond
The Role Of Foxd1 In Clear Cell Renal Cell Carcinoma, Kyle H. Bond
Electronic Theses and Dissertations
Renal cell carcinoma (RCC) is the 8th most common cancer in the United States, with the clear cell variant (ccRCC) being the most prevalent. Over 14,000 people die every year to RCC, with rates continuing to increase with an aging general population. Patients suffering from metastatic RCC (mRCC) have extremely poor prognoses, with a 5-year survival of only 11.2%. Current treatment options include resection of primary lesions, tyrosine kinase inhibition (Sunitinib, Pazopanib), mTOR inhibition (Temsirolimus, Everolimus), and immune checkpoint inhibition (Nivolumab, Atezolizumab). Recent attention has been drawn to inhibition of transcription factors like HIF2α (Belzutifan). There is a need …
Understanding The Adhesion Mechanism In Mycelium-Assisted Wood Bonding, Wenjing Sun
Understanding The Adhesion Mechanism In Mycelium-Assisted Wood Bonding, Wenjing Sun
Electronic Theses and Dissertations
The increasing environmental awareness has led to an increased interest in developing more sustainable materials as alternatives to petroleum-derived products. Among different nature-based products, fungal-mycelium-based bio-composites have gained considerable attention in various applications. Multiple materials with different densities and structures and potential applications can be fabricated by inoculating filamentous white-rot fungi in lignocellulosic materials and other substrates. Different from lower-density as-grown foam-like mycelium composites, higher-density mycelium-lignocellulosic panels have the potential to replace commercial particleboard and fiberboard bonded by petroleum-based resins. This kind of composite can be produced by directly adding heat and pressure to the low-density foams or by assembling …
Development Of A Bacteriophage-Based Portable Biosensor For The Detection Of Shiga-Toxin Producing Escherichia Coli (Stec) Strains In Food And Environmental Matrices, Irwin A. Quintela
Development Of A Bacteriophage-Based Portable Biosensor For The Detection Of Shiga-Toxin Producing Escherichia Coli (Stec) Strains In Food And Environmental Matrices, Irwin A. Quintela
Electronic Theses and Dissertations
A fast and reliable on-site foodborne pathogens screening can reduce the incidence of foodborne illnesses, hospitalizations and economic loss. It can also circumvent conventional laboratory-based tests with minimal sample treatments and shorter turnaround time. Rapid detection of biological hazards has been largely dependent on immunological agents (ie antibodies). Antibodies are expensive to manufacture and experience cross-reactivity, instability with shorter shelf life. Our aim was to improve the screening process of Shiga-toxin producing Escherichia coli (STEC) strains in food and environmental matrices by developing a novel, inexpensive handheld bacteriophage-based amperometric biosensor that can directly detect live STEC cells.This biosensor development began …