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Bioinformatic Analysis And In Vitro Expression Of Malaria Parasite Translocon And Ribonuclease Binding-Like Rhoptry Genes, Moses Z. Timta

ETD Archive

Malaria caused by the parasite Plasmodium, still remains a significant public health problem worldwide, due to lack of a vaccine and emerging drug and insecticide resistance, among malaria parasites and mosquito vectors, respectively. Rhoptry proteins of Plasmodium enable merozoite invasion of host erythrocytes. However, only a few of these proteins have been characterized. Thirty-six P. yoelii merozoite rhoptry proteins were identified as putative rhoptry proteins by proteome analysis. Some of these proteins have been characterized while others still remain an intense area of active research. Molecular characterization and understanding of these novel proteins may assist in vaccine development, design of …