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Full-Text Articles in Biology
Cerebellar Degeneration In Harlequin Mice Is Associated With Inflammation Unaltered By Low-Dose Phenobarbital Treatment, Anita Prtenjaca
Cerebellar Degeneration In Harlequin Mice Is Associated With Inflammation Unaltered By Low-Dose Phenobarbital Treatment, Anita Prtenjaca
Electronic Thesis and Dissertation Repository
Canadian population demographics are shifting to an increase in aged individuals and an increase in the prevalence of neurodegenerative diseases. The post-mitotic nature of most neurons highlights the need to understand the etiology and early mechanisms in neurodegenerative diseases and design targeted therapies. Currently, the etiologies of neurodegeneration are poorly understood but oxidative stress, mitochondrial dysfunction and inflammation are early mechanisms in Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis. An anti-aging strategy that can be adapted for use in neurodegeneration is hormesis, where repeated low-level exposures to stressors are beneficial to the cell. Hormesis has demonstrated efficacy in inhibiting …
Endotoxin-Induced Inflammation & Morphine-Induced Conditioned Place Preference In The Hiv-1 Transgenic Rat, Natasha F. Homji-Mishra
Endotoxin-Induced Inflammation & Morphine-Induced Conditioned Place Preference In The Hiv-1 Transgenic Rat, Natasha F. Homji-Mishra
Seton Hall University Dissertations and Theses (ETDs)
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House Dust Mite Induced Gene Expression And Cytokine Secretion By Human Dermal Fibroblasts, Jananie Rockwood
House Dust Mite Induced Gene Expression And Cytokine Secretion By Human Dermal Fibroblasts, Jananie Rockwood
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House dust mites are a group of mites that are commonly found in homes worldwide. The three most commonly found species of house dust mites in temperate environments in the United States are Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei. House dust mite allergens are strongly associated with asthma, perennial rhinitis and atopic dermatitis. Whole dust mite extracts contain both allergen and non-allergen molecules that can influence cell functions in the skin, mucous membranes of the nose and eyes, and epithelial linings of the lungs. Extracts from the three different house dust mite species contain different molecules that induce different …