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Age Related Changes In The Activity And The Responsiveness Of The Renin-Angiotensin System In The 15 Month Old Rat, Michele Mckee Thompson
Age Related Changes In The Activity And The Responsiveness Of The Renin-Angiotensin System In The 15 Month Old Rat, Michele Mckee Thompson
Dissertations and Theses
Progressive deterioration of renal function is one consequence of aging. Glomerular maladaptation is one aspect of this and includes increased glomerular capillary hypertension and a reduced ultrafiltration coefficient, which can lead to glomerular sclerosis and proteinuria. In the aging rat, angiotensin converting enzyme inhibitors (CEI) lower proteinuria (UprotV) and decrease glomerular sclerosis (2, 18, 24, 45). Accordingly, alterations in the circulating and renal renin-angiotensin system (RAS) are hypothesized to play a role in the pathogenesis of renal disease in the aging rat. Previous studies using rat models have demonstrated a lower responsiveness to converting enzyme inhibitor treatment in …