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Full-Text Articles in Biology
Hybrid Carbon-Based Scaffolds For Applications In Soft Tissue Reconstruction, Jarema S. Czarnecki, Khalid Lafdi, Robert M. Joseph, Panagiotis A. Tsonis
Hybrid Carbon-Based Scaffolds For Applications In Soft Tissue Reconstruction, Jarema S. Czarnecki, Khalid Lafdi, Robert M. Joseph, Panagiotis A. Tsonis
Biology Faculty Publications
Current biomedical scaffolds utilized in surgery to repair soft tissues commonly fail to meet the optimal combination of biomechanical and tissue regenerative properties. Carbon is a scaffold alternative that potentially optimizes the balance between mechanical strength, durability, and function as a cell and biologics delivery vehicle that is necessary to restore tissue function while promoting tissue repair. The goals of this study were to investigate the feasibility of fabricating hybrid fibrous carbon scaffolds modified with biopolymer, polycaprolactone and to analyze their mechanical properties and ability to support cell growth and proliferation. Environmental scanning electron microscopy, micro-computed tomography, and cell adhesion …
Adapting Biodegradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels For Pigment Epithelial Cell Encapsulation And Lens Regeneration, Mimi W. Zhang, Hansoo Park, Xuan Guo, Kenta Nakamura, Robert M. Raphael, F. Kurtis Kasper, Antonios G. Mikos, Panagiotis A. Tsonis
Adapting Biodegradable Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels For Pigment Epithelial Cell Encapsulation And Lens Regeneration, Mimi W. Zhang, Hansoo Park, Xuan Guo, Kenta Nakamura, Robert M. Raphael, F. Kurtis Kasper, Antonios G. Mikos, Panagiotis A. Tsonis
Biology Faculty Publications
This study investigated the encapsulation of newt iris pigment epithelial cells (PECs), which have the ability to regenerate a lens by trans-differentiation in vivo, within a biodegradable hydrogel of oligo(poly(ethylene glycol) fumarate) crosslinked with poly(ethylene glycol)-diacrylate. Hydrogel beads of initial diameter of 1mm were fabricated by a molding technique. The swelling ratio and degradation rate of the hydrogel beads decreased with increasing crosslinking ratios. Confocal microscopy confirmed the cytocompatibility of crosslinking hydrogel formulations as evidenced by the viability of an encapsulated model cell line within a crosslinked hydrogel bead. Hydrogel beads encapsulating iris PECs were also implanted into lentectomized newts …
A Novel Approach To Control Growth, Orientation, And Shape Of Human Osteoblasts, Jarema S. Czarnecki, Khalid Lafdi, Panagiotis A. Tsonis
A Novel Approach To Control Growth, Orientation, And Shape Of Human Osteoblasts, Jarema S. Czarnecki, Khalid Lafdi, Panagiotis A. Tsonis
Biology Faculty Publications
Carbon-based materials are considered to be promising materials as implants because of their unique mechanical and biocompatibility properties. The current paper investigates the use of carbon-based materials as a functional interface for tissue scaffolds and medical implants. Three basic parameters were explored such as graphene orientation, crystallinity and surface interaction. To explore the effect of the orientation, samples were made with and without a preferred carbon orientation. Conversely, the crystallinity was studied using graphitic and carbonaceous matrices. Fluorescent, confocal and environmental scanning microscopy was used to visualize cell response. The cell attachment, proliferation and elongation were prevalent on the unidirectional …