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Evaluation Of Anticancer Activity Of Heterocyclic Arylidenes On The U87mg Cancer Cell Line, Bernadette Flores

Honors Theses

Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of hybrid compounds, heterocyclic arylidenes, containing various functional groups, including boronic acids, through a three-day testing process. These compounds were previous synthesized …