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Full-Text Articles in Biology
Rna Secondary Structure Of 3’Utr Regulates Translation Control, M. Grace Hren
Rna Secondary Structure Of 3’Utr Regulates Translation Control, M. Grace Hren
Biological Sciences
According to the central dogma of biology, DNA is transcribed into mRNA. This mRNA is then translated into a protein. Translation of mRNA into protein is extremely precise, and as such is controlled by many different factors, both spatially and temporally. This phenomenon is known as translation control. Many times, this regulation is influenced by secondary structures, often in the form of stem loops on the mRNA. These secondary structures found on mRNA, specifically in the 3’Untranslated Region (3’UTR) of mRNA, can influence cellular gene expression. These genes can be upregulated or down regulated, depending on stem loop function. When …
Tissue-Specific Thyroid Hormone Regulation Of Gene Transcripts Encoding Iodothyronine Deiodinases And Thyroid Hormone Receptors In Striped Parrotfish (Scarus Iseri), Kaitlin M. Johnson, Sean C. Lema
Tissue-Specific Thyroid Hormone Regulation Of Gene Transcripts Encoding Iodothyronine Deiodinases And Thyroid Hormone Receptors In Striped Parrotfish (Scarus Iseri), Kaitlin M. Johnson, Sean C. Lema
Biological Sciences
In fish as in other vertebrates, the diverse functions of thyroid hormones are mediated at the peripheral tissue level through iodothyronine deiodinase (dio) enzymes and thyroid hormone receptor (tr) proteins. In this study, we examined thyroid hormone regulation of mRNAs encoding the three deiodinases dio1, dio2 and dio3 – as well as three thyroid hormone receptors trαA, trαB and trβ – in initial phase striped parrotfish (Scarus iseri). Parrotfish were treated with dissolved phase T3 (20 nM) or methimazole (3 mM) for 3 days. Treatment with exogenous T3 elevated circulating T3, while the …
The Role Of Trna Modification Systems In The Cellular Stress Response, Margaret Daly
The Role Of Trna Modification Systems In The Cellular Stress Response, Margaret Daly
Biological Sciences
Transfer RNA(tRNA) is a small chain of nucleotides that participates in protein synthesis by pairing its anticodon with an mRNA codon and transferring an amino acid to a growing polypeptide chain. tRNA methyltransferases are a group of enzymes that can modify nucleosides in or around the anticodon, as well as at other parts of the tRNA. Recently, some of these modifications have been reported to enhance the translation of proteins that help the cell respond to and/or repair DNA damage. We hypothesize that the modifications catalyzed by some of the tRNA methyltransferases (Trms) stabilize the interaction between the mRNA codon …