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Quantification Of Fibrosis And Infiltrates In The Salivary Gland, Nikhita Kumar
Quantification Of Fibrosis And Infiltrates In The Salivary Gland, Nikhita Kumar
Biological Sciences
Fibrosis is characterized by the excessive buildup of extracellular matrix components (ECM) in tissues and organs in response to injury, chronic inflammation, auto immune disorders, and genetic alterations. Non-obese diabetic mice (NOD) are a model for Sjögren’s Syndrome. We hypothesize that NOD mice, which start to develop Sjögren’s-like disease at approximately 12 weeks of age are suffering from hyposalivation at least in part due to fibrosis of the submandibular salivary glands (SMGs). Fibrosis refers to the over-production of extracellular matrix proteins in the connective tissue compartment. To test this hypothesis 16-week-old mice were treated with either the fibrosis inhibitor Nintedanib …
The Role Of Angiocrine Factors In The Progression Of Salivary Disease, Owen Zon
The Role Of Angiocrine Factors In The Progression Of Salivary Disease, Owen Zon
Biological Sciences
In our blood vessels, cells called endothelial cells line the inside of veins and arteries. Due to the discovery that endothelial cells actually organogenesis during embryogenesis, our interest in these cells has increased to a new understanding of their functions in tissue repair and regeneration. These cells are no longer only considered passive modes of transport for bodily fluids and nutrients, but, with new research in the fibrosis of liver cells, are also considered to be key players in the repair of damaged organs and tissue. These cells release signals known as angiocrine factors that act in damaged areas of …
How Salivary Glands Recover From Fibrotic Injury, Gabriella Majka
How Salivary Glands Recover From Fibrotic Injury, Gabriella Majka
Biological Sciences
Extracellular matrix deposition is required for repair after injury, but if left unresolved can result in fibrosis. Fibrosis is an excess deposition of extracellular matrix proteins following injury or aging that leads to eventual organ dysfunction. One surgical model that we have used to study mechanisms of fibrosis is the salivary gland ductal ligation model. During the process of ligation, a clip is placed on the main ducts of the submandibular (SMG) and sublingual gland (SLG) which leads from the salivary glands to the mouth. This causes the gland to atrophy, or waste away, resulting in decreased acinar cell differentiation …