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Articles 1 - 8 of 8
Full-Text Articles in Biology
Determining The Effect Of Absorbents And Soybean Systems On Pfas Precursor Transformation, Tamia Wellington
Determining The Effect Of Absorbents And Soybean Systems On Pfas Precursor Transformation, Tamia Wellington
Biological Sciences
PFAS (Per- and polyfluoroalkyl substances) refers to a class of chemicals that consist of long-chains of carbon bonded to fluorine. These are chemicals that have many industrial uses, from cosmetics to industrial fire-fighting foam. Since PFAS is so widely used and available, it has become increasingly present in water and soil, resulting in its uptake and bioaccumulation in plants. This study focused on the impacts of powdered activated carbon (PAC) and montmorillonite on the PFOS precursor N-ethyl perfluorooctane sulfonamido acetic acid (N-EtFOSAA), in soil, and in plants grown in that soil. This study focused on spiking soil with PFAS chemicals, …
Determining The Functional Roles Of Short Open Reading Frames In Mycobacterium Smegmatis, Lauren Fox
Determining The Functional Roles Of Short Open Reading Frames In Mycobacterium Smegmatis, Lauren Fox
Biological Sciences
The study examines the roles of a subset of short open reading frames (sORFs) in M. smegmatis using targeted mutagenesis and the subsequent examination of phenotypes associated with sORF mutation or overexpression. sORFs are defined as stretches of nucleic acid encoding a protein with a maximum of 50 amino acids. Genome annotation pipelines overlook sORFs encoding small proteins (sproteins) and, thus, sproteins in bacteria have gone unnoticed, even those that are expressed at levels similar to larger, well-described proteins. As a result of recent advances in ribosome profiling and mass spectrometry, hundreds of previously unannotated sORFs have been identified, increasing …
Quantification Of Fibrosis And Infiltrates In The Salivary Gland, Nikhita Kumar
Quantification Of Fibrosis And Infiltrates In The Salivary Gland, Nikhita Kumar
Biological Sciences
Fibrosis is characterized by the excessive buildup of extracellular matrix components (ECM) in tissues and organs in response to injury, chronic inflammation, auto immune disorders, and genetic alterations. Non-obese diabetic mice (NOD) are a model for Sjögren’s Syndrome. We hypothesize that NOD mice, which start to develop Sjögren’s-like disease at approximately 12 weeks of age are suffering from hyposalivation at least in part due to fibrosis of the submandibular salivary glands (SMGs). Fibrosis refers to the over-production of extracellular matrix proteins in the connective tissue compartment. To test this hypothesis 16-week-old mice were treated with either the fibrosis inhibitor Nintedanib …
Improvement Of Depressive-Like Behaviors In Hemi-Parkinsonian Rats With Non-Invasive Peripheral Focused Ultrasound Modulation, Hudy Berger
Biological Sciences
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease with marked loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). In PD, there are motor and non-motor symptoms. Depression, a non-motor symptom, is seen in 40% of the patients with PD which decreases their quality of life. For treatment-resistant depression, vagus nerve stimulation (VNS) has been shown to improve depression. Here, non-invasive focused ultrasound (FUS) is investigated as a therapeutic to improve depression-like behavior by targeting the celiac plexus since it is innervated by the vagus nerve. FUS was chosen due to its parallel mechanism to VNS. …
Investigating The Effects Of Vitamin K1 And K2 On The Triple Negative Breast Cancer Cell Line Sum159pt, Monica E. Alexander
Investigating The Effects Of Vitamin K1 And K2 On The Triple Negative Breast Cancer Cell Line Sum159pt, Monica E. Alexander
Biological Sciences
Vitamin K serves as a cofactor in the post-translational carboxylation of glutamate to γ-carboxyglutamate (GLA) by the enzyme gamma-glutamyl carboxylase (GGCX). Vitamin K epoxide reductases (VKOR) then oxidize the vitamin K to regenerate the compound’s reduced form. While most of the known γcarboxylated proteins function in coagulation and bone homeostasis, the presence of GGCX and VKOR in a wide variety of tissues suggests that the vitamin and its pathway has more extensive physiological roles. Our previous research has assessed the expression of the vitamin K pathway in triple negative breast cancer cells (TNBCs) and compared the effects of vitamin K1 …
Progress Towards Peptide And Protein Synthesis Involving Thiol Moieties, Ryan Lo Chen
Progress Towards Peptide And Protein Synthesis Involving Thiol Moieties, Ryan Lo Chen
Biological Sciences
Polypeptides and proteins play crucial roles in biological systems, including enzymatic activity regulation, molecule transport, and cell and tissue structural support. Amino acids are the building blocks of peptides and proteins, and peptides can act as hormones, neurotransmitters, and enzymes. Proteins are made up of one or more polypeptide chains and have diverse functions such as catalyzing chemical reactions, transporting molecules, and providing structural support. Protein preparation can be done biologically by expression systems or isolation and purification from natural sources. While these methods have their advantages, they also have their shortcomings. Chemical synthesis is an alternative method that allows …
Characterization Of Protein-Protein Interactions In Quorum-Sensing Receptors From Gram Negative Bacteria, Jessica Schuh
Characterization Of Protein-Protein Interactions In Quorum-Sensing Receptors From Gram Negative Bacteria, Jessica Schuh
Biological Sciences
Pseudomonas aeruginosa is a bacterium capable of causing disease in immunocompromised individuals and individuals with underlying lung disorders. It controls the expression of a subset of its genes through quorum sensing, which is a cell-cell communication system involved in mediating the transition from individual to group behaviors. Group behaviors are cellular processes undertaken by the cell that are beneficial to the collective, such as biofilm formation – a key component of pathogenesis in the human lung. They rely on the production, accumulation, detection, and response to signal molecules called autoinducers. There are two acyl-homoserine lactone autoinducer quorum sensing systems in …
A Review Of The Forensic Applications For The Analysis Of Biological Fluids Using Fluorescence Spectroscopy, Raghavi Patel
A Review Of The Forensic Applications For The Analysis Of Biological Fluids Using Fluorescence Spectroscopy, Raghavi Patel
Biological Sciences
The use of science to compile information to assist in solving crimes is known as forensic science. Numerous bodily fluids, such as blood, semen, saliva, and vaginal fluid, are frequently discovered at crime scenes. This makes it crucial for forensic scientists to use analytical methods to examine these fluids to learn more about the crime, including the offender, victim, time since deposition, and other details. Although there are many techniques, the focus of this paper is fluorescence spectroscopy. Fluorescence spectroscopy is a rapid, inexpensive, and non-destructive technique used for forensic examination (Weber & Lednev, 2022). Fluorescence spectroscopy can be used …