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The Rck/P54 Prion-Related Domain And Its Influence On The Localization And Function Of Rck/P54 During Hcv Infection, Lindsey Oltz
The Rck/P54 Prion-Related Domain And Its Influence On The Localization And Function Of Rck/P54 During Hcv Infection, Lindsey Oltz
Biological Sciences
Currently over 180 million people are infected with Hepatitis C virus (HCV) worldwide. HCV infection is a major cause of hepatocellular carcinoma (HCC), liver cirrhosis, and chronic hepatitis. The available antiviral treatment of interferon and ribavirin has limited success, is costly and toxic. Furthermore, there is no vaccine. An increased understanding of how HCV exploits the many cellular pathways and host factors during infection will provide information necessary for the development of novel anti-HCV therapies, which target host proteins rather than the rapidly evolving viral proteins. During infection, HCV interacts with and manipulates many host mRNA pathways. The Pager lab …