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Distinct Microbiome In Pouchitis Compared To Healthy Pouches In Ulcerative Colitis And Familial Adenomatous Polyposis, Garrett C. Zella, Elizabeth J. Hait, Tiffany Glavan, Dirk Gevers, Doyle V. Ward, Christopher L. Kitts, Joshua R. Korzenik
Distinct Microbiome In Pouchitis Compared To Healthy Pouches In Ulcerative Colitis And Familial Adenomatous Polyposis, Garrett C. Zella, Elizabeth J. Hait, Tiffany Glavan, Dirk Gevers, Doyle V. Ward, Christopher L. Kitts, Joshua R. Korzenik
Biological Sciences
Background: Pouchitis occurs in up to 50% of patients with ulcerative colitis (UC) undergoing ileal pouch anal anastomosis (IPAA). Pouchitis rarely occurs in patients with familial adenomatous polyposis (FAP) who undergo IPAA. Our aim was to compare mucosal and luminal flora in patients with UC-associated pouchitis (UCP), healthy UC pouches (HUC), and healthy FAP pouches (FAP).
Methods: Nineteen patients were enrolled in thi s cross-sectional study (nine UCP, tl1ree HUC, seven FAP). Patie nts with active pouchitis were identified using the Pouchitis Disease Activity Index (PDAI). Ileal pouch mucosal biopsies and fecal samples were analyzed with a 16S rDNA-based terminal …