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The Anti-Epileptic Drugs Phenytoin And Valproate Produce Reproductive Endocrine Dysfunction Among Reproductive Endocrine Dysfunction Among Female Rats Through Its Effects On Progesterone And Its 5 Alpha-Reduced Metabolites, Fareed Haddad
Biological Sciences
Background: Many people with seizure disorder experience reproductive endocrine dysfunction (RED). The extent to which RED is due to intrinsic aspects of seizure disorder, and/or therapies used to manage epilepsy, is not well understood. Many anti-epileptic drugs (AEDs), such as phenytoin or valproate, can have effects that alter endocrine status. Phenytoin is a cytochrome p450 enzyme-inducing drug. Valproate is a cytochrome p450 enzyme-reducing AED. Objective: To evaluate the effects and mechanism of some AEDs on RED in a rodent model. Hypothesis: If AEDs produce RED in part by altering the activities of cytochrome p450 enzymes, then AEDs that disrupt estrous …