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Activation Of The Ppar Nuclear Receptors By Oxylipins And Their Potential Effects On Differentiation And Gene Expression In Myocytes, Jazmine Eccles
Activation Of The Ppar Nuclear Receptors By Oxylipins And Their Potential Effects On Differentiation And Gene Expression In Myocytes, Jazmine Eccles
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Obesity and non-alcoholic fatty liver diseases are a growing issue worldwide. Decreased expression of CYP2B6 is associated with obesity in humans and Cyp2b-null mice are diet-induced obese; however fatty liver disease is worse in humanized CYP2B6 transgenic mice than WT or Cyp2b-null mice despite lower obesity. CYP2B6 produces several oxylipins with preference for metabolism at the 9- and 13-positions with 9-HODE and 13-HODE (from linoleic acid; n-6), and 9-HOTrE and 13-HOTrE (from a-linolenic acid; n-3) preferentially produced. Oxylipins serve as signaling molecules for many processes, such as inflammatory pathways, lipid distribution, and lipid metabolism. Due to their diversity, oxylipins can …