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Full-Text Articles in Biology

Modulation Of The Host Response To Tacaribe Arenavirus Infection In Ag129 Mice By My-24, Eric Sefing Dec 2012

Modulation Of The Host Response To Tacaribe Arenavirus Infection In Ag129 Mice By My-24, Eric Sefing

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

MY-24 is a new antiviral compound recently shown to protect immunocompromised mice from lethal challenge with Tacaribe virus (TCRV). Tacaribe virus is incapable of causing disease to humans, but is closely related to the highly pathogenic New World arenaviruses that cause often-fatal viral hemorrhagic fever syndromes. Remarkably, MY-24 prevents mortality without reducing virus burden in the circulation or tissues. To investigate the mechanism by which MY-24 protects AG129 mice against Tacaribe virus infection, we first characterized the natural history of disease in the model with an emphasis on host immune response and blood vessel function to establish the best times …


Caddisfly Larvae (Limnephilidae) As Predators Of Newt (Taricha Granulosa) Eggs: Another Player In The Coevolutionary Arms Race Revolving Around Tetrodotoxin?, Brian G. Gall May 2012

Caddisfly Larvae (Limnephilidae) As Predators Of Newt (Taricha Granulosa) Eggs: Another Player In The Coevolutionary Arms Race Revolving Around Tetrodotoxin?, Brian G. Gall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Some populations of newts (Taricha granulosa) possess large quantities of the neurotoxin tetrodotoxin (TTX) in their skin and eggs. Many populations of garter snake (Thamnophis sirtalis) are resistant to this toxin and can consume large numbers of newts with no negative effects. Despite the wealth of information acquired on the interaction between newts and their predator, garter snakes, very little research has been conducted on possible interactions between newts and other predators. I conducted a suite of experiments examining for the presence of other predators on newts, specifically focusing on predators of their eggs and larvae. …


Characterization Of The Function And Interaction Of Proteins Involved In Exopolysaccharide Synthesis In Streptococcus Thermophilus, Streptococcus Iniae, And Lactococcus Lactis Subsp. Cremoris, Angela D. Cefalo May 2012

Characterization Of The Function And Interaction Of Proteins Involved In Exopolysaccharide Synthesis In Streptococcus Thermophilus, Streptococcus Iniae, And Lactococcus Lactis Subsp. Cremoris, Angela D. Cefalo

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Many microorganisms produce capsules of repeating sugar units that surround the cell called exopolysaccharides. The synthesis of these capsules is a complex process that involves numerous protein components. A better understanding of the way these proteins function and interact with one another will benefit many industrial processes by aiding in the construction of bacterial strains with enhanced properties and could also lead to new treatment strategies against microbial pathogens in which capsule production is important in their ability to cause disease. In this study, the function of one of the proteins involved in the regulation of capsule synthesis in the …


Clark's Nutcracker Seed Harvest Patterns In Glacier National Park And A Novel Method For Monitoring Whitebark Pine Cones, Monika E. Maier May 2012

Clark's Nutcracker Seed Harvest Patterns In Glacier National Park And A Novel Method For Monitoring Whitebark Pine Cones, Monika E. Maier

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Clark's Nutcracker (Nucifraga columbiana) is the primary seed disperser of whitebark pine (Pinus albicaulis), which is in decline throughout its range. There is concern that a decline in whitebark pine will lead to a subsequent decline in local populations of Clark's Nutcracker. Because natural regeneration depends on the presence of Clark's Nutcracker, the process of harvesting whitebark pine seeds needs to be fully understood. In addition, resource managers need a cost-effective method for monitoring nutcracker occurrence in whitebark pine stands during the seed harvest season. I visited eleven study sites in Glacier National Park, Montana, where …


Social Organization And Decision Making In North American Bison: Implications For Management, Ryan A. Shaw May 2012

Social Organization And Decision Making In North American Bison: Implications For Management, Ryan A. Shaw

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Social organization varies widely among herbivores, and the level of social organization in bison is widely debated. I hypothesized that when mother-daughter relationships are allowed to develop, bison form long-term associations. In my study, 25 treatment mothers were selected from a free-ranging herd and kept together with their calves, while 25 control females had their calves forcefully removed. Treatment mothers and offspring had by far the greatest number of associations with a greater percentage of individuals with a half weight index (HWI) > 0.50. The strongest associations (HWI > 0.31) were among treatment mothers and their offspring. Moreover, these associations persisted over …