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Characterization Of The Clostridioides Difficile Glycosyl Hydrolase Ccsz, Brian Lowrance
Characterization Of The Clostridioides Difficile Glycosyl Hydrolase Ccsz, Brian Lowrance
Theses and Dissertations (Comprehensive)
Bacteria inhabit many of the harshest environments on Earth; persisting and thriving in conditions thought to be unsuitable for life. One common strategy to withstand these environments is the formation of a biofilm. Biofilm composition varies greatly, depending on the underlying community that produces it. Cellulose, a polymer consistently prevalent in biofilms, has been identified as a virulence factor in many pathogens and is suspected to be involved in pathogenesis by Clostridioides difficile. C. difficile is the #1 cause of hospital acquired diarrhea, which can range from mild to life-threatening infections. Biofilm formation is hypothesized to be involved in …
Purification And Characterization Of Bcsc; An Integral Component Of Bacterial Cellulose Export, Emily D. Wilson Ms
Purification And Characterization Of Bcsc; An Integral Component Of Bacterial Cellulose Export, Emily D. Wilson Ms
Theses and Dissertations (Comprehensive)
Biofilms are a growing concern in the medical field due to their increased resistance to antibiotics. When found in a biofilm, bacteria can have antibiotic resistance 10-1000 times that of their planktonic counterparts. Therefore, it is important to study the formation of biofilms. Cellulose biofilms are formed by Enterobacteriaceae, such as many Escherichia coli and Salmonella spp. strains. Biofilms provide these species with benefits including antimicrobial protection, development of bacterial communities, promotion of DNA exchange, uptake of nutrients, and, in the case of cellulose biofilms, immune system evasion. Cellulose biofilms are controlled by the Bacterial cellulose synthesis (Bcs) complex located …
Impact Of Biofilm Formation And Composition On Antibiotic Resistance In Environmental Isolates Of Escherichia Coli And Salmonella Spp., Raluca Tutulan
Impact Of Biofilm Formation And Composition On Antibiotic Resistance In Environmental Isolates Of Escherichia Coli And Salmonella Spp., Raluca Tutulan
Theses and Dissertations (Comprehensive)
Escherichia coli and Salmonella spp., like most bacteria, prefer to grow in biofilms. These biofilms provide bacteria with protection from harsh environmental factors (such as desiccation and changes in pH), aid in the evasion of host immune responses and provide increased antibiotic resistance. Biofilms are present in non-host environments (e.g. water pipes) as well as in mammalian hosts (in the healthy gastrointestinal microbiota and in over 65% of nosocomial infections). Two important components utilized by E. coli and Salmonella spp. to form biofilms are cellulose and curli fimbriae. Curli fimbriae mediate the attachment of bacteria to abiotic surfaces and …