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Full-Text Articles in Biology
Synthesis And Preliminary Antimicrobial Analysis Of Isatin- Ferrocene And Isatin-Ferrocenyl Chalcone Conjugates, Amandeep Singh, Grant Fong, Jenny Liu, Yun-Hsuan Wu, Kevin Chang, William Park, Jihwan Kim, Christina Tam, Luisa W. Cheng, Kirkwood M. Land, Vipan Kumar
Synthesis And Preliminary Antimicrobial Analysis Of Isatin- Ferrocene And Isatin-Ferrocenyl Chalcone Conjugates, Amandeep Singh, Grant Fong, Jenny Liu, Yun-Hsuan Wu, Kevin Chang, William Park, Jihwan Kim, Christina Tam, Luisa W. Cheng, Kirkwood M. Land, Vipan Kumar
College of the Pacific Faculty Articles
In this study, we outline the synthesis of isatin-ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 μM. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 μM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new …
In Vitro Activity Of Four Fluoroquinolones On Selected Bacteria, Sheryl L. Pullen
In Vitro Activity Of Four Fluoroquinolones On Selected Bacteria, Sheryl L. Pullen
University of the Pacific Theses and Dissertations
In 1990-1991, in a national surveillance study, and in 1991-1992, in a followup study, both by Thornsberry et al. (1993), ciprofloxacin data from various geographical and demographical institutions were collected. Several species of bacteria have shown resistance to ciprofloxacin and norfloxacin, but the degree of resistance to these drugs has not been reported for the Stockton area. To determine the extent of this resistance, Dameron Hospital antibiograms generated from 1990 to 1994 were reviewed and compared. Results of the comparison show that susceptibility among the Gram-negative isolates, with the exception of Providencia stuartii, Acinetobacter lwoffi, and to a lesser extent …
Studies On An Antibiotic-Producing Strain Of Bacillus Megaterium X, Kishori Madhukar Chaubal
Studies On An Antibiotic-Producing Strain Of Bacillus Megaterium X, Kishori Madhukar Chaubal
University of the Pacific Theses and Dissertations
On July 10, 1968, while observing the effects of ultra-violet light on a plate culture of Sarcino lutea, o contaminant was found growing in the form of a colony surrounded by a clear zone of inhibition where S. lutea had failed to grow. A smear from this contaminant colony was found to contain a Gram positive, chain-ond spore-forming bacillus. The organism was isolated and its antagonism against S. lutea was reshocked. Preliminary investigation of its activity against other bacteria indicated that this activity was directed against 5. lutea only. I was decided to continue the investigations with two aims in …