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Functional Characterization Of P90/Cip2a In Human Lung Cancer, Bo Peng
Functional Characterization Of P90/Cip2a In Human Lung Cancer, Bo Peng
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p90/CIP2A is a recently characterized oncoprotein which promotes cancer cell proliferation through the inhibition of c-myc-associated PP2A phosphatase activity, from which it derived the name as cancerous inhibitor of PP2A (CIP2A). Although p90/CIP2A has been found to be overexpressed in various cancer types, from solid tumors to hematological malignancies, the function of this protein is still limited to its ability to regulate the stability of c-myc. The recent study showing p90/CIP2A is able to regulate the phosphorylation of protein kinase B (PKB) in response to the treatment of chemotherapy drugs implied p90/CIP2A may have more functions. In order to investigate …