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Osteopontin Plays A Pivotal Role In In Increasing Severity Of Respiratory Syncytial Virus Infection, Viviana Sampayo-Escobar
Osteopontin Plays A Pivotal Role In In Increasing Severity Of Respiratory Syncytial Virus Infection, Viviana Sampayo-Escobar
USF Tampa Graduate Theses and Dissertations
The molecular mechanisms underlying susceptibility to severe respiratory syncytial virus (RSV) infection remain poorly understood. Herein, we report on the role of osteopontin (OPN) in regulation of RSV infection in human epithelial cells and how interleukin-1 beta (IL-1β), a cytokine secreted soon after RSV infection, when persistently expressed can induce OPN expression leading to increased viral infection. We first compared OPN expression in two human epithelial cell lines: HEK-293 and HEp-2. In contrast to HEp-2, HEK-293 expresses low levels of pro-caspase-1 resulting in decreased IL-1β expression in response to RSV infection. We found a correlation between low IL-1β levels and …