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Homocysteine: A Potential Molecular Link Between Alzheimer's Disease And Type 2 Diabetes Mellitus, Cyndel Carreau
Homocysteine: A Potential Molecular Link Between Alzheimer's Disease And Type 2 Diabetes Mellitus, Cyndel Carreau
Biological Sciences
In order to elucidate some of the mechanisms through which Alzheimer’s disease (AD) and Type II Diabetes Mellitus (T2DM) are linked, this study investigated the effects of elevated plasma homocysteine levels – a risk factor for AD – in a rat model of T2DM. Both elevated plasma homocysteine levels and T2DM are associated with cognitive deficits and are recognized as strong risk factors for the development of AD. The present experiment examined the effects of diet-induced hyperhomocysteinemia on the development of cognitive impairments and insulin-resistance, as well as on the insulin signaling cascade, in a diet-induced obese rat model of …