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Full-Text Articles in Biology
Selfish Mitochondrial Dna Proliferates And Diversifies In Small, But Not Large, Experimental Populations Of Caenorhabditis Briggsae, Wendy S. Phillips, Anna Luella Coleman-Hulbert, Emily S. Weiss, Dana K. Howe, Sita Ping, Riana I. Wernick, Suzanne Estes, Dee R. Denver
Selfish Mitochondrial Dna Proliferates And Diversifies In Small, But Not Large, Experimental Populations Of Caenorhabditis Briggsae, Wendy S. Phillips, Anna Luella Coleman-Hulbert, Emily S. Weiss, Dana K. Howe, Sita Ping, Riana I. Wernick, Suzanne Estes, Dee R. Denver
Biology Faculty Publications and Presentations
Evolutionary interactions across levels of biological organization contribute to a variety of fundamental processes including genome evolution, reproductive mode transitions, species diversification, and extinction. Evolutionary theory predicts that so-called “selfish” genetic elements will proliferate when the host effective population size (Ne) is small, but direct tests of this prediction remain few. We analyzed the evolutionary dynamics of deletion-containing mitochondrial DNA (ΔmtDNA) molecules, previously characterized as selfish elements, in six different natural strains of the nematode Caenorhabditis briggsae allowed to undergo experimental evolution in a range of population sizes (N = 1, 10, 100, and 1,000) for a maximum …
Phenotypic And Mutational Consequences Of Mitochondrial Etc Genetic Damage, Michael James Lue
Phenotypic And Mutational Consequences Of Mitochondrial Etc Genetic Damage, Michael James Lue
Dissertations and Theses
Genetic mutation is the ultimate source of new phenotypic variation in populations. The importance of mutation cannot be understated, and constitutes a significant evolutionary force. Although single mutations may have little to no impact on organismal performance or fitness, when multiplied across the total number of potential sites within the genome, mutation can have a large impact. Accurate measurement of the rates, molecular mechanisms, and distributions of effects of mutations are critical for many applications of evolutionary theory. Despite the importance of both deleterious and beneficial mutations, their genome-wide patterns and phenotypic consequences are poorly understood when considering the mitochondrial …