Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biology
The Role Of Pyrococcus Furiosus Transcription Factor E In Transcription Iniitiation, Robyn Lynn Eustis
The Role Of Pyrococcus Furiosus Transcription Factor E In Transcription Iniitiation, Robyn Lynn Eustis
Dissertations and Theses
All sequenced archaeal genomes encode a general transcription factor, TFE, which is highly conserved and homologous to the alpha subunit of the eukaryotic transcription factor TFIIE. TFE functions to increase promoter opening efficiency during transcription initiation, although the mechanism for this is unclear. The N-terminus of TFE contains a common DNA binding motif, a winged helix. At the tip of this winged helix is a highly conserved region of aromatic amino acids that is close to DNA during initiation. TFE activation can compensate for mutations in another transcription factor, TFB2, which is homologous to TFIIB. P. furiosus encodes two paralogs …
Gene Expression Patterns That Support Novel Developmental Stress Buffering In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Josiah T. Wagner, Jason E. Podrabsky
Gene Expression Patterns That Support Novel Developmental Stress Buffering In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Josiah T. Wagner, Jason E. Podrabsky
Biology Faculty Publications and Presentations
Background: The cellular signaling mechanisms and morphogenic movements involved in axis formation and gastrulation are well conserved between vertebrates. In nearly all described fish, gastrulation and the initial patterning of the embryonic axis occur concurrently with epiboly. However, annual killifish may be an exception to this norm. Annual killifish inhabit ephemeral ponds in South America and Africa and permanent populations persist by the production of stress-tolerant eggs. Early development of annual killifish is unique among vertebrates because their embryonic blastomeres disperse randomly across the yolk during epiboly and reaggregate several days later to form the embryo proper. In addition, annual …