Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biology
The Role Of Neuropilin-1 In Covid-19, Bindu Mayi, Jillian A. Leibowitz, Arden T. Woods, Katherine A. Ammon, Alphonse E. Liu, Aarti Raja
The Role Of Neuropilin-1 In Covid-19, Bindu Mayi, Jillian A. Leibowitz, Arden T. Woods, Katherine A. Ammon, Alphonse E. Liu, Aarti Raja
Biology Faculty Articles
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro. This cell surface receptor with its disseminated expression is important in angiogenesis, tumor progression, viral entry, axonal guidance, and immune function. NRP-1 is implicated in several aspects of a SARS-CoV-2 infection including possible spread through the olfactory bulb and into the central nervous system and increased NRP-1 RNA expression in lungs of severe Coronavirus Disease 2019 (COVID-19). Up-regulation of NRP-1 protein in diabetic kidney cells hint at its importance in a population at …