Biology Commons^™

Photoperiod Manipulation Reveals A Light-Driven Component To Daily Patterns Of Ventilation In Male C57bl/6j Mice, Aaron A. Jones, Lauren R. Nelson, Gabriella M. Marino, Nakia A. Chappelle, Deborah A.M. Joye, Deanna M. Arble

Biological Sciences Faculty Research and Publications

Obstructive sleep apnea is a common sleep disorder that increases risk for cardiovascular disease and mortality. The severity of sleep-disordered breathing in obstructive sleep apnea patients fluctuates with the seasons, opening the possibility that seasonal changes in light duration, or photoperiod, can influence mechanisms of breathing. Photoperiod can have profound effects on internal timekeeping and can reshape metabolic rhythms in mammals. While the daily rhythm in ventilation is largely shaped by the metabolic rate, less is known about whether ventilatory rhythms are altered in accordance with metabolism under different photoperiods. Here, we investigate the relationship between ventilation and metabolism under …