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Hypothalamic Pituitary Adenylate Cyclase-Activating Polypeptide: Impact On Energy Homeostasis And Glutamate Signaling, Jon Resch
Dissertations (1934 -)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the secretin-glucagon superfamily of peptide hormones, with homology to vasoactive intestinal polypeptide (VIP) and activity at both the VIP receptors and the PACAP specific PAC1 receptor (PAC1R). Abundantly expressed in the hypothalamus, PACAP was recently discovered to regulate energy balance when central injections produced hypophagia and increased metabolic rate. However, the neurocircuitry mediating these effects in the hypothalamus are poorly understood.
To characterize how hypothalamic PACAP signaling affects energy homeostasis we microinjected PACAP site-specifically into the hypothalamic paraventricular (PVN) and ventromedial nuclei (VMN) and examined feeding behavior and metabolism. PACAP injected …