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The Role Of Prka-Mediated Stimulation Of Fatty Acid Oxidation In The Regulation Of Meiotic Maturation In Mouse Oocytes, Deepa Valsangkar
The Role Of Prka-Mediated Stimulation Of Fatty Acid Oxidation In The Regulation Of Meiotic Maturation In Mouse Oocytes, Deepa Valsangkar
Dissertations (1934 -)
Meiosis is a defining aspect of sexual reproduction and its outcome often determines reproductive success. In mammalian females, oocytes initiate meiosis in early embryonic stages but arrest in the late prophase of meiosis-I around the time of birth. They remain arrested until hormonal induction during reproductive cycles after puberty, and then resume meiosis until a second arrest at metaphase-II. The process of oocyte meiosis from the release of prophase arrest till the metaphase-II arrest is known as oocyte maturation. Meiotic arrest is a result of maintenance of elevated cAMP levels within the oocyte by its continuous production as well as …