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Five Myofibrillar Lesion Types In Eccentrically Challenged, Unloaded Rat Adductor Longus Muscle—A Test Model, Joyce L. Thompson, Edward Michael Balog, Robert H. Fitts, Danny A. Riley
Five Myofibrillar Lesion Types In Eccentrically Challenged, Unloaded Rat Adductor Longus Muscle—A Test Model, Joyce L. Thompson, Edward Michael Balog, Robert H. Fitts, Danny A. Riley
Biological Sciences Faculty Research and Publications
Sarcomere disruptions are observed in the adductor longus (AL) muscles following voluntary reloading of spaceflown and hindlimb suspension unloaded (HSU) rat, which resemble lesions in eccentrically challenged muscle. We devised and tested an eccentric contraction (ECCON) test system for the 14-day HSU rat AL. Six to 7 hours following ECCON, ALs were fixed to allow immunostaining and electron microscopy (EM). Toluidine blue-stained histology semithin sections were screened for lesion density (#/mm2). Serial semithin sections from the ECCON group were characterized for myosin immunointensity of lesions. Five myofibrillar lesion types were identified in histological semithin sections: focal contractions; wide …