Biology Commons^™

Physiological And Morphological Correlates Of Presynaptic Inhibition In Primary Afferents Of The Lamprey Spinal Cord, I. V. Batueva, E. A. Tsvetkov, A. K. Sagatelyan, James T. Buchanan, N. Vesselkin, V. Adanina, E. I. Suderevskaya, J. -P Rio, J. Repérant

Biological Sciences Faculty Research and Publications

Patch-clamp recordings in a whole-cell mode were performed on dorsal sensory cells enzymatically isolated from the spinal cord of two lamprey species, Ichthyomyzon unicuspis and Lampetra fluviatilis. The voltage-activated currents through calcium channels were analysed. GABA and the specific GABA_B receptor agonist baclofen reduced the peak amplitude of inward Ba²⁺ current, as a robust alternate charge carrier through voltage-dependent Ca²⁺ channels. These effects were dose-dependent and reversible. GABA_B receptor antagonists, 2-hydroxysaclofen and δ-amino-n-valeric acid, blocked the reduction of Ba²⁺ currents by GABA and baclofen, while bicuculline, a GABA_A receptor antagonist, had no blocking …